Abstract：
As a member of the neonicotinoid group, imidaclothiz has garnered increasing attention due to its possible health risks. This study investigated the metabolism and distribution of imidaclothiz in mice. Seven imidaclothiz metabolites were found, four of which are known, and three are unknown. The metabolic reactions observed were hydroxylation, nitrate ester hydrolysis, methylation, urea formation, and reduction to NO. Precise quantification revealed that after 2 h of oral administration, imidaclothiz rapidly dispersed into various organs and tissues, peaking at 4 h, and was then swiftly eliminated. No propensity for accumulation in the body, particularly in the liver, was observed. Toxicity data from the T.E.S.T prediction indicated that imidaclothiz had moderate toxicity to rats, and a majority of its metabolites were more toxic than the parent compound. These findings complement the existing knowledge of the imidaclothiz environmental fate in mammals and offer a reference point for its application in agriculture and industry.
摘要：
作为新烟碱类药物的一员，吡虫啉因其可能的健康风险而受到越来越多的关注。本研究调查了吡喃酮在小鼠体内的代谢和分布。发现了七种吡虫啉代谢物,其中四个是已知的，三个是未知的。观察到的代谢反应是羟基化，硝酸酯水解，甲基化,尿素形成，减少到NO。精确定量显示，口服2小时后，吡虫啉迅速分散到各种器官和组织中，在4小时达到峰值，然后迅速被淘汰。没有在体内积累的倾向，特别是在肝脏中，被观察到。来自T.E.S.T预测的毒性数据表明，吡虫啉对大鼠具有中等毒性，它的大部分代谢物比母体化合物毒性更大。这些发现补充了现有的关于哺乳动物中吡虫啉环境命运的知识，并为其在农业和工业中的应用提供了参考。
