Abstract：
OBJECTIVE: Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery.
METHODS: MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
RESULTS: A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
CONCLUSIONS: This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.
METHODS: MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival.
RESULTS: A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies.
CONCLUSIONS: This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.
摘要：
目的：肿瘤的组织学分级是一个公认的生物标志物，用于指导女性乳腺癌的治疗。然而,其在男性乳腺癌中的意义尚不清楚。本系统综述调查了接受手术的男性乳腺癌患者肿瘤分级与乳腺癌特异性生存率（BCSS）的预后意义。
方法：MEDLINE，搜索PUBMEDCentral和EMBASE数据库，以确定与男性乳腺肿瘤相关的随机试验和观察性研究。肿瘤分级，复发,和生存。
结果：本综述共纳入了15项观察性研究。在大多数研究中报道了肿瘤分级和BCSS之间的显著关联。这种关联在高级别（III级）与低级别（I级）肿瘤相比最为明显。在4项研究中的4项具有显著的关系。对于中度II级肿瘤，在少数研究中证明了相关性。
结论：这项研究证实了高级别男性乳腺癌与较差的疾病特异性生存率之间的关联。然而,中级肿瘤的意义尚不清楚.需要进一步的研究来调查男性乳腺癌的生物学与组织学分级的关系，并最佳地定义中级疾病。
方法：MEDLINE，搜索PUBMEDCentral和EMBASE数据库，以确定与男性乳腺肿瘤相关的随机试验和观察性研究。肿瘤分级，复发,和生存。
结果：本综述共纳入了15项观察性研究。在大多数研究中报道了肿瘤分级和BCSS之间的显著关联。这种关联在高级别（III级）与低级别（I级）肿瘤相比最为明显。在4项研究中的4项具有显著的关系。对于中度II级肿瘤，在少数研究中证明了相关性。
结论：这项研究证实了高级别男性乳腺癌与较差的疾病特异性生存率之间的关联。然而,中级肿瘤的意义尚不清楚.需要进一步的研究来调查男性乳腺癌的生物学与组织学分级的关系，并最佳地定义中级疾病。
