Abstract：
Therapeutic hypothermia is now well established to improve neurodevelopmental outcomes after hypoxic-ischemic encephalopathy (HIE). Although the overall principles of treatment are now well established, many smaller questions are unclear. The potential impact of reversal of hypothermia therapy and the effect of high temperatures on recovery of the neurovascular unit after therapeutic hypothermia for HIE has received relatively little attention. This article will address the effects of hypoxia-ischemia and rewarming and increased temperatures on the neurovascular unit in preclinical and clinical models.
摘要：
目前已经建立了治疗性低温治疗以改善缺氧缺血性脑病（HIE）后的神经发育结果。虽然治疗的总体原则现在已经确立，许多较小的问题不清楚。低温疗法逆转的潜在影响以及高温对HIE治疗性低温后神经血管单元恢复的影响很少受到关注。本文将讨论临床前和临床模型中缺氧缺血和复温以及温度升高对神经血管单元的影响。
