%0 Journal Article
%T Reverse Therapy: Impact of Hyperthermia and Rewarming on Newborn Outcomes.
%A Chalak LF
%A Davidson JO
%A Gunn AJ
%J Clin Perinatol
%V 51
%N 3
%D 2024 Sep
%M 39095096
%F 2.642
%R 10.1016/j.clp.2024.04.002
%X Therapeutic hypothermia is now well established to improve neurodevelopmental outcomes after hypoxic-ischemic encephalopathy (HIE). Although the overall principles of treatment are now well established, many smaller questions are unclear. The potential impact of reversal of hypothermia therapy and the effect of high temperatures on recovery of the neurovascular unit after therapeutic hypothermia for HIE has received relatively little attention. This article will address the effects of hypoxia-ischemia and rewarming and increased temperatures on the neurovascular unit in preclinical and clinical models.