Abstract：
Alzheimer\'s disease (AD) is the most prevalent type of dementia; therefore, there is a high demand for therapeutic medication targeting it. In this context, extensive research has been conducted to identify molecular targets for drugs. AD manifests through two primary pathological signs: senile plaques and neurofibrillary tangles, caused by accumulations of amyloid-beta (Aβ) and phosphorylated tau, respectively. Thus, studies concerning the molecular mechanisms underlying AD etiology have primarily focused on Aβ generation and tau phosphorylation, with the anticipation of uncovering a signaling pathway impacting these molecular processes. Over the past two decades, studies using not only experimental model systems but also examining human brains have accumulated fragmentary evidences suggesting that REELIN signaling pathway is deeply involved in AD. Here, we explore REELIN signaling pathway and its involvement in memory function within the brain and review studies investigating molecular connections between REELIN signaling pathway and AD etiology. This review aims to understand how the manipulation (activation) of this pathway might ameliorate the disease\'s etiology.
摘要：
阿尔茨海默病(AD)是最常见的痴呆类型;因此,对针对它的治疗药物有很高的需求。在这种情况下，已经进行了广泛的研究以确定药物的分子靶标。AD通过两个主要的病理征象表现：老年斑和神经原纤维缠结，由β淀粉样蛋白（Aβ）和磷酸化tau的积累引起，分别。因此，有关AD病因的分子机制的研究主要集中在Aβ的产生和tau磷酸化，预期会发现影响这些分子过程的信号通路。在过去的二十年里，不仅使用实验模型系统，而且检查人脑的研究已经积累了零碎的证据，表明REELIN信号通路与AD密切相关。这里,我们探讨了REELIN信号通路及其在脑内记忆功能中的作用,并回顾了研究REELIN信号通路与AD病因之间分子联系的研究.这篇综述旨在了解该途径的操纵（激活）如何改善疾病的病因。
