OBJECTIVE: The current review summarizes the mechanism of NF-κB dysregulation in different subtypes of RCC and its impact on pathogenesis.
UNASSIGNED: This review highlights the prominent role of NF-κB in RCC development and progression by driving the expression of multiple genes and interplaying with different pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. In silico analysis of RCC cohorts and molecular studies have revealed that multiple NF-κB members and target genes are dysregulated. The dysregulation includes receptors such as TLR2, signal-transmitting members including RelA, and target genes, for instance, HIF-1α. The lack of effective regulatory mechanisms results in a constitutively active NF-κB pathway, which promotes cancer growth, migration, and survival. In this review, we comprehensively summarize the role of dysregulated NF-κB-related genes in the most common subtypes of RCC, including clear cell RCC (ccRCC), chromophobe RCC (chRCC), and papillary RCC (PRCC).
目的:综述NF-κB调控异常在不同亚型RCC中的作用机制及其对发病的影响。
■这篇综述通过驱动多个基因的表达和与不同途径的相互作用,突出了NF-κB在RCC发生和进展中的重要作用。包括磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)途径。RCC队列的计算机模拟分析和分子研究表明,多个NF-κB成员和靶基因失调。失调包括受体,如TLR2,信号传递成员,包括RelA,和目标基因,例如,HIF-1α。缺乏有效的调节机制导致组成型活性的NF-κB途径,促进癌症生长,迁移,和生存。在这次审查中,我们全面总结了NF-κB相关基因在RCC最常见亚型中的作用,包括透明细胞RCC(ccRCC),发色细胞RCC(chRCC),和乳头状RCC(PRCC)。