PDF(Pubmed)
Abstract：
BACKGROUND: The aim of this study was to evaluate the efficacy and safety of formula milk powder in the treatment of lactose intolerance in children, and to provide an evidence-based medicine basis for the rational use of drugs in children with lactose intolerance caused by various reasons by meta-analysis.
METHODS: Use computers to search major databases, including Web of Science, PubMed, CNKI, Wanfang Data Knowledge Service Platform, and other databases, the retrieval time is from the establishment of the database to April 2023. The collected literatures were screened, data extracted and processed, and then meta-analysis was performed by Review-Manager 5.4 statistical software.
RESULTS: A total of 10 randomized controlled trials were included, with 1112 patients, including 562 patients in the treatment group and 550 patients in the control group. The control group was treated with conventional therapy, and the treatment group was treated with lactose-free/low-lactose milk powder on the basis of conventional therapy. The results of the meta-analysis showed that the clinical efficacy of the treatment group was significantly better than that of the control group [odds ratio=6.01, 95% confidence interval (CI): 3.94-9.18, P<0.00001], the course of disease in the treatment group was shorter than that in the control group (mean difference=-1.45, 95% CI: -1.76 to -1.13, P<0.0001). The antidiarrhea time of the treatment group was shorter than that of the control group, and the difference between the 2 groups was statistically significant (mean difference=-1.41, 95% CI: -1.67 to -1.15, P<0.0001).
CONCLUSIONS: Low/lactose-free milk powder can improve clinical efficacy and shorten the course of treatment in infants with lactose intolerance, which can be demonstrated by further large-scale clinical studies.
METHODS: Use computers to search major databases, including Web of Science, PubMed, CNKI, Wanfang Data Knowledge Service Platform, and other databases, the retrieval time is from the establishment of the database to April 2023. The collected literatures were screened, data extracted and processed, and then meta-analysis was performed by Review-Manager 5.4 statistical software.
RESULTS: A total of 10 randomized controlled trials were included, with 1112 patients, including 562 patients in the treatment group and 550 patients in the control group. The control group was treated with conventional therapy, and the treatment group was treated with lactose-free/low-lactose milk powder on the basis of conventional therapy. The results of the meta-analysis showed that the clinical efficacy of the treatment group was significantly better than that of the control group [odds ratio=6.01, 95% confidence interval (CI): 3.94-9.18, P<0.00001], the course of disease in the treatment group was shorter than that in the control group (mean difference=-1.45, 95% CI: -1.76 to -1.13, P<0.0001). The antidiarrhea time of the treatment group was shorter than that of the control group, and the difference between the 2 groups was statistically significant (mean difference=-1.41, 95% CI: -1.67 to -1.15, P<0.0001).
CONCLUSIONS: Low/lactose-free milk powder can improve clinical efficacy and shorten the course of treatment in infants with lactose intolerance, which can be demonstrated by further large-scale clinical studies.
摘要：
背景：这项研究的目的是评估配方奶粉治疗儿童乳糖不耐受的疗效和安全性，并通过Meta分析为各种原因引起的乳糖不耐受患儿的合理用药提供循证医学依据。
方法：使用计算机搜索主要数据库，包括WebofScience,PubMed,CNKI,万方数据知识服务平台,和其他数据库，检索时间是从数据库建立到2023年4月。对收集的文献进行筛选,数据提取和处理，然后通过Review-Manager5.4统计软件进行荟萃分析。
结果：共纳入10项随机对照试验，1112名患者,其中治疗组562例,对照组550例。对照组采用常规治疗,治疗组在常规治疗基础上加用无乳糖/低乳糖奶粉。Meta分析结果显示,治疗组临床疗效明显优于对照组[比值比=6.01,95%置信区间(CI):3.94~9.18,P<0.00001],治疗组病程短于对照组(均差=-1.45,95%CI:-1.76~-1.13,P<0.0001)。治疗组的止泻时间明显短于对照组,两组之间的差异有统计学意义（平均差异=-1.41，95％CI：-1.67至-1.15，P<0.0001）。
结论：低/无乳糖奶粉可提高乳糖不耐受婴幼儿的临床疗效，缩短疗程。这可以通过进一步的大规模临床研究来证明。
方法：使用计算机搜索主要数据库，包括WebofScience,PubMed,CNKI,万方数据知识服务平台,和其他数据库，检索时间是从数据库建立到2023年4月。对收集的文献进行筛选,数据提取和处理，然后通过Review-Manager5.4统计软件进行荟萃分析。
结果：共纳入10项随机对照试验，1112名患者,其中治疗组562例,对照组550例。对照组采用常规治疗,治疗组在常规治疗基础上加用无乳糖/低乳糖奶粉。Meta分析结果显示,治疗组临床疗效明显优于对照组[比值比=6.01,95%置信区间(CI):3.94~9.18,P<0.00001],治疗组病程短于对照组(均差=-1.45,95%CI:-1.76~-1.13,P<0.0001)。治疗组的止泻时间明显短于对照组,两组之间的差异有统计学意义（平均差异=-1.41，95％CI：-1.67至-1.15，P<0.0001）。
结论：低/无乳糖奶粉可提高乳糖不耐受婴幼儿的临床疗效，缩短疗程。这可以通过进一步的大规模临床研究来证明。
