Abstract：
The efficiency of combinations of cytostatics cisplatin and adriamycin with antioxidant sodium 3-(3\'-tert-butyl-4-hydroxyphenyl)propyl thiosulfate (TS-13), and nitric oxide (NO) donor NaNO2 was evaluated on two drug-resistant strains of leukemia P388 with changed redox-status of cells. Simultaneous use of both NO donor and TS-13 in combinations with the cytostatics did not increase the efficiency of therapy. In addition, antioxidant activity of TS-13, NaNO2, and their combinations was studied by the method of luminol-dependent chemiluminescence on the model systems with the use of the homogenized cells of sensitive strain and two drug-resistant strains of leukemia P388. It was shown that TS-13 and NO donor produced opposite effects: TS-13 decreased, while NO donor increased the content of free radicals in the model system. Combinations of antioxidant TS-13 and NO donor should be used with consideration for the redox-status of tumor treated.
摘要：
细胞抑制剂顺铂和阿霉素与抗氧化剂3-（3'-叔丁基-4-羟基苯基）丙基硫代硫酸钠（TS-13）的组合的效率，和一氧化氮（NO）供体NaNO2在两种耐药的白血病P388菌株上进行了评估，并改变了细胞的氧化还原状态。与细胞抑制剂组合同时使用NO供体和TS-13并未提高治疗效率。此外,TS-13，NaNO2及其组合的抗氧化活性通过鲁米诺依赖性化学发光方法在模型系统上使用敏感菌株和两个耐药白血病P388菌株的匀浆细胞进行了研究。结果表明，TS-13和NO供体产生相反的作用：TS-13降低，NO供体增加了模型体系中自由基的含量。应使用抗氧化剂TS-13和NO供体的组合，同时考虑所治疗肿瘤的氧化还原状态。
