%0 Journal Article
%T Redox-Active Compounds in the Therapy of Drug-Resistant Murine Leukemia P388 Strains.
%A Raevskaya TA
%A Soldatova YV
%A Goncharova SA
%A Faingold II
%J Bull Exp Biol Med
%V 177
%N 2
%D 2024 Jun 2
%M 39093476
%F 0.737
%R 10.1007/s10517-024-06170-4
%X The efficiency of combinations of cytostatics cisplatin and adriamycin with antioxidant sodium 3-(3'-tert-butyl-4-hydroxyphenyl)propyl thiosulfate (TS-13), and nitric oxide (NO) donor NaNO2 was evaluated on two drug-resistant strains of leukemia P388 with changed redox-status of cells. Simultaneous use of both NO donor and TS-13 in combinations with the cytostatics did not increase the efficiency of therapy. In addition, antioxidant activity of TS-13, NaNO2, and their combinations was studied by the method of luminol-dependent chemiluminescence on the model systems with the use of the homogenized cells of sensitive strain and two drug-resistant strains of leukemia P388. It was shown that TS-13 and NO donor produced opposite effects: TS-13 decreased, while NO donor increased the content of free radicals in the model system. Combinations of antioxidant TS-13 and NO donor should be used with consideration for the redox-status of tumor treated.