PDF(Pubmed)
Abstract：
Sarcomas comprise between 10-15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and young adults. These tumors are commonly treated with surgery and/or radiation therapy and combination chemotherapy. However, there is a strong need for the development and utilization of targeted therapeutic methods to improve patient outcomes. Towards accomplishing this goal, pre-clinical models for these unique malignancies are of particular importance to design and test experimental therapeutic strategies prior to being introduced to patients due to their origination site and propensity to metastasize. Pre-clinical models offer several advantages for the study of pediatric sarcomas with unique benefits and shortcomings dependent on the type of model. This review addresses the types of pre-clinical models available for the study of pediatric solid tumors, with special attention to the bone sarcomas osteosarcoma and Ewing sarcoma.
摘要：
肉瘤占所有儿科恶性肿瘤的10-15%。骨肉瘤和尤因肉瘤是在儿童和年轻人中诊断出的两种最常见的小儿骨肿瘤。这些肿瘤通常用手术和/或放射疗法和组合化学疗法治疗。然而,非常需要开发和利用有针对性的治疗方法来改善患者的预后.为了实现这个目标，这些独特恶性肿瘤的临床前模型对于设计和测试实验性治疗策略尤其重要,因为这些恶性肿瘤的起源部位和转移倾向.临床前模型为小儿肉瘤的研究提供了一些优势，具有独特的益处和缺点，取决于模型的类型。这篇综述介绍了可用于儿科实体瘤研究的临床前模型的类型。特别注意骨肉瘤骨肉瘤和尤因肉瘤。
