METHODS: This retrospective study collected NSCC diagnosed in our dermatology department between 2007 and 2021. The histopathological features were correlated with the clinical signs and immunohistochemistry.
RESULTS: A total of 48 patients were included, and immunohistochemistry was available for 36 of them. Two histopathological patterns became prominent: a blue-basaloid type characterized by koilocytosis (p < 0.001), and a pink-keratinizing type. Mean ages were similar when comparing basaloid and periungual versus keratinizing and subungual (p < 0.001). p16 was positive in 31 of 36 cases: 18 basaloid and 13 keratinizing (p = 0.167). p53 and Ki67 were all abnormal.
CONCLUSIONS: Our study described two histopathological NSCC subtypes and associated them with the two clinical subtypes: the blue-basaloid type, HPV-induced, in situ, of periungual localization in younger males; and the pink-keratinizing type, non-HPV-induced, invasive, of subungual site, in elderly. Immunohistochemistry was not contributing on its own, but p16 positivity associated with basaloid histopathological profile helps support HPV etiology.
方法:这项回顾性研究收集了2007年至2021年在我们皮肤科诊断的NSCC。组织病理学特征与临床体征和免疫组织化学相关。
结果:共纳入48例患者,其中36例可用免疫组织化学。两种组织病理学模式变得突出:以空红细胞增多症(p<0.001)为特征的蓝色基底细胞型,和粉红色角质化类型。比较基底细胞和甲周与角化和甲下的平均年龄相似(p<0.001)。36例中有31例p16阳性:18个基底细胞和13个角化(p=0.167)。p53和Ki67均异常。
结论:我们的研究描述了两种组织病理学的NSCC亚型,并将它们与两种临床亚型相关联:蓝色基底细胞型,HPV诱导,在原地,年轻男性的甲周定位;和粉红色角化型,非HPV诱导,侵入性,subugual网站,在老年人。免疫组织化学本身没有贡献,但与基底细胞样组织病理学特征相关的p16阳性有助于支持HPV病因。