PDF(Pubmed)
Abstract：
Although previous studies have suggested that meteorological factors and air pollutants can cause dry eye disease (DED), few clinical cohort studies have determined the individual and combined effects of these factors on DED. We investigated the effects of meteorological factors (humidity and temperature) and air pollutants [particles with a diameter ≤ 2.5 μ m (PM2.5), ozone (O3), nitrogen dioxide (NO2), and carbon monoxide (CO)] on DED. A retrospective cohort study was conducted on 53 DED patients. DED was evaluated by Symptom Assessment in Dry Eye (SANDE), tear secretion, tear film break-up time (TBUT), ocular staining score (OSS), and tear osmolarity. To explore the individual, non-linear, and joint associations between meteorological factors, air pollutants, and DED parameters, we used generalized linear mixed model (GLMM) and Bayesian kernel machine regression (BKMR). After adjusting for all covariates, lower relative humidity or temperature was associated with a higher SANDE (p < 0.05). Higher PM2.5, O3, and NO2 levels were associated with higher SANDE and tear osmolarity (p < 0.05). Higher O3 levels were associated with lower tear secretion and TBUT, whereas higher NO2 levels were associated with higher OSS (p < 0.05). BKMR analyses indicated that a mixture of meteorological factors and air pollutants was significantly associated with increased SANDE, OSS, tear osmolarity, and decreased tear secretion.
摘要：
尽管先前的研究表明气象因素和空气污染物会导致干眼病（DED），很少有临床队列研究确定了这些因素对DED的个体和综合影响.我们调查了气象因素（湿度和温度）和空气污染物[直径≤2.5μm（PM2.5）的颗粒，臭氧(O3)二氧化氮(NO2),和一氧化碳（CO）]在DED上。对53例DED患者进行了回顾性队列研究。DED通过干眼症状评估（SANDE）进行评估，泪液分泌,泪膜破裂时间（TBUT），眼部染色评分（OSS），和眼泪渗透压。探索个体,非线性，和气象因素之间的联合关联，空气污染物,和DED参数，我们使用广义线性混合模型(GLMM)和贝叶斯核机回归(BKMR)。在调整所有协变量后，较低的相对湿度或温度与较高的SANDE相关(p<0.05)。较高的PM2.5、O3和NO2水平与较高的SANDE和泪液渗透压相关(p<0.05)。较高的O3水平与较低的泪液分泌和TBUT有关，而较高的NO2水平与较高的OSS相关(p<0.05)。BKMR分析表明，气象因素和空气污染物的混合与SANDE增加显着相关，OSS,泪液渗透压,泪液分泌减少。
