Abstract：
UNASSIGNED: Prenatal protein malnutrition produces anatomical and functional changes in the developing brain that persist despite immediate postnatal nutritional rehabilitation. Brain networks of prenatally malnourished animals show diminished activation of prefrontal areas and an increased activation of hippocampal regions during an attentional task [1]. While a reduction in cell number has been documented in hippocampal subfield CA1, nothing is known about changes in neuron numbers in the prefrontal or parahippocampal cortices.
UNASSIGNED: In the present study, we used unbiased stereology to investigate the effect of prenatal protein malnutrition on the neuron numbers in the medial prefrontal cortex and the cortices of the parahippocampal region that comprise the larger functional network.
UNASSIGNED: Results show that prenatal protein malnutrition does not cause changes in the neuronal population in the medial prefrontal cortex of adult rats, indicating that the decrease in functional activation during attentional tasks is not due to a reduction in the number of neurons. Results also show that prenatal protein malnutrition is associated with a reduction in neuron numbers in specific parahippocampal subregions: the medial entorhinal cortex and presubiculum.
UNASSIGNED: The affected regions along with CA1 comprise a tightly interconnected circuit, suggesting that prenatal malnutrition confers a vulnerability to specific hippocampal circuits. These findings are consistent with the idea that prenatal protein malnutrition produces a reorganization of structural and functional networks, which may underlie observed alterations in attentional processes and capabilities.
UNASSIGNED: In the present study, we used unbiased stereology to investigate the effect of prenatal protein malnutrition on the neuron numbers in the medial prefrontal cortex and the cortices of the parahippocampal region that comprise the larger functional network.
UNASSIGNED: Results show that prenatal protein malnutrition does not cause changes in the neuronal population in the medial prefrontal cortex of adult rats, indicating that the decrease in functional activation during attentional tasks is not due to a reduction in the number of neurons. Results also show that prenatal protein malnutrition is associated with a reduction in neuron numbers in specific parahippocampal subregions: the medial entorhinal cortex and presubiculum.
UNASSIGNED: The affected regions along with CA1 comprise a tightly interconnected circuit, suggesting that prenatal malnutrition confers a vulnerability to specific hippocampal circuits. These findings are consistent with the idea that prenatal protein malnutrition produces a reorganization of structural and functional networks, which may underlie observed alterations in attentional processes and capabilities.
摘要：
目的：产前蛋白质营养不良会在发育中的大脑中产生解剖和功能变化，尽管产后立即进行营养康复，但这种变化仍然存在。产前营养不良动物的大脑网络显示，在注意力任务期间，前额叶区域的激活减少，海马区域的激活增加[1]。尽管已在海马子区CA1中记录了细胞数量的减少，但对前额叶或海马旁皮质中神经元数量的变化一无所知。方法：在本研究中，我们使用无偏倚的体视学研究了产前蛋白质营养不良对内侧前额叶皮质和构成更大功能网络的海马旁区域皮质神经元数量的影响.结果:结果表明,产前蛋白质营养不良不会引起成年大鼠内侧前额叶皮质神经元群的变化,表明注意力任务期间功能激活的减少不是由于神经元数量的减少。结果还表明，产前蛋白质营养不良与特定海马旁亚区域的神经元数量减少有关：内侧内嗅皮层和前丘。讨论：受影响的区域以及CA1包括紧密互连的电路，这表明产前营养不良赋予特定海马回路的脆弱性。这些发现与产前蛋白质营养不良会导致结构和功能网络重组的观点一致，这可能是观察到的注意过程和能力改变的基础。
