PDF(Pubmed)
Abstract：
We report the familial occurrence of a severe phenotype of central serous chorioretinopathy (CSC). A 62-year-old man was referred to our institute to treat a macular lesion in his right eye. Best-corrected visual acuity (BCVA) in his right eye was 0.05 (decimal format). On the initial visit, swept-source optical coherence tomography (SS-OCT) demonstrated subretinal hyperreflective material (SHRM) and subretinal fluid involving the central macula in the right eye and a descending tract on fundus autofluorescence (FAF) in the left eye, and fluorescein angiography revealed focal leakage corresponding to choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA) of the right eye. He received photodynamic therapy (PDT) for the right eye and exudation disappeared. His 66-year-old elder brother had a medical history of CSC in both eyes and had received treatment at our hospital at 61 years old. On the initial presentation, ICGA showed multiple CVH in both eyes, and FAF showed hypofluorescence corresponding to retinal pigment epithelium (RPE) tears and RPE atrophy in both eyes. Bullous retinal detachment (RD) developed inferiorly in both eyes, and a vitrectomy was performed for the right eye to repair RD. The baseline BCVA was 0.3 in both eyes. Two years after the initial visit, recurrent serous RD developed in his left eye, and multiple PDT sessions were performed during the six-year follow-up. A severe phenotype of CSC may be associated with a genetic background.
摘要：
我们报告了家族性发生的严重表型的中心性浆液性脉络膜视网膜病变（CSC）。一名62岁的男子被转诊到我们的研究所治疗右眼黄斑病变。右眼的最佳矫正视力（BCVA）为0.05（十进制格式）。在最初的访问中，扫频源光学相干断层扫描（SS-OCT）显示视网膜下超反射材料（SHRM）和视网膜下液累及右眼中央黄斑和左眼眼底自发荧光下降道（FAF），和荧光素血管造影显示，右眼吲哚菁绿血管造影（ICGA）上与脉络膜血管通透性过高（CVH）相对应的局灶性渗漏。他接受了右眼光动力疗法（PDT），渗出消失。他66岁的哥哥双眼有CSC病史，61岁时在我院接受治疗。在最初的介绍中，ICGA显示双眼多发CVH,FAF显示出与双眼视网膜色素上皮（RPE）撕裂和RPE萎缩相对应的低荧光。双眼大疱性视网膜脱离（RD）发育不良，右眼行玻璃体切除术修复RD。双眼的基线BCVA为0.3。初次访问两年后，他的左眼出现复发性浆液性RD，在6年随访期间进行了多次PDT治疗.CSC的严重表型可能与遗传背景有关。
