PDF(Pubmed)
Abstract：
UNASSIGNED: Amiodarone is a class III antiarrhythmic drug that is commonly used in the clinic to treat ventricular arrhythmias and atrial fibrillation. We present a case report of the adverse effects of amiodarone and review its characteristics.
UNASSIGNED: A 73-year-old Asian female with a history of paroxysmal atrial fibrillation managed with amiodarone, well-controlled hypertension, and no substance abuse presented with gastrointestinal distress and dizziness, without chest pain or palpitations. Despite normal annual check-ups, she developed abnormal liver and thyroid function tests, and imaging revealed lung and liver changes suggestive of amiodarone toxicity. Discontinuation of amiodarone for sotalol led to symptom improvement and normalization of thyroid and liver functions, with imaging indicating recovery from interstitial fibrosis and reduced liver density.
UNASSIGNED: Amiodarone, a widely used for treating ventricular and atrial arrhythmias, and with significant benefits in improving patient survival in cases of ventricular fibrillation. However, its long-term use is associated with serious adverse effects, including thyroid dysfunction, liver injury, and pulmonary toxicity, necessitating careful monitoring and management. Despite its efficacy, the need for research on early detection and management of amiodarone\'s side effects is crucial, highlighting the importance of regular monitoring and possibly adjusting therapy to mitigate these risks.
UNASSIGNED: A 73-year-old Asian female with a history of paroxysmal atrial fibrillation managed with amiodarone, well-controlled hypertension, and no substance abuse presented with gastrointestinal distress and dizziness, without chest pain or palpitations. Despite normal annual check-ups, she developed abnormal liver and thyroid function tests, and imaging revealed lung and liver changes suggestive of amiodarone toxicity. Discontinuation of amiodarone for sotalol led to symptom improvement and normalization of thyroid and liver functions, with imaging indicating recovery from interstitial fibrosis and reduced liver density.
UNASSIGNED: Amiodarone, a widely used for treating ventricular and atrial arrhythmias, and with significant benefits in improving patient survival in cases of ventricular fibrillation. However, its long-term use is associated with serious adverse effects, including thyroid dysfunction, liver injury, and pulmonary toxicity, necessitating careful monitoring and management. Despite its efficacy, the need for research on early detection and management of amiodarone\'s side effects is crucial, highlighting the importance of regular monitoring and possibly adjusting therapy to mitigate these risks.
摘要：
■胺碘酮是一种III类抗心律失常药物，在临床上常用于治疗室性心律失常和心房颤动。我们介绍了胺碘酮不良反应的病例报告，并回顾了其特征。
■一位73岁的亚裔女性，有阵发性心房颤动病史，接受胺碘酮治疗，良好控制的高血压，并且没有出现胃肠道不适和头晕的药物滥用，没有胸痛或心悸。尽管进行了正常的年度检查,她的肝脏和甲状腺功能检查异常,影像学显示肺和肝脏变化提示胺碘酮毒性。停用胺碘酮治疗索他洛尔可改善症状并使甲状腺和肝功能正常化，影像学显示间质纤维化恢复和肝脏密度降低。
■胺碘酮,广泛用于治疗室性和房性心律失常，在改善室颤患者的生存率方面具有显着的益处。然而,它的长期使用会带来严重的不良影响，包括甲状腺功能障碍,肝损伤,和肺毒性，需要仔细监测和管理。尽管它的功效,需要研究早期发现和管理胺碘酮的副作用是至关重要的，强调定期监测和可能调整治疗以减轻这些风险的重要性。
■一位73岁的亚裔女性，有阵发性心房颤动病史，接受胺碘酮治疗，良好控制的高血压，并且没有出现胃肠道不适和头晕的药物滥用，没有胸痛或心悸。尽管进行了正常的年度检查,她的肝脏和甲状腺功能检查异常,影像学显示肺和肝脏变化提示胺碘酮毒性。停用胺碘酮治疗索他洛尔可改善症状并使甲状腺和肝功能正常化，影像学显示间质纤维化恢复和肝脏密度降低。
■胺碘酮,广泛用于治疗室性和房性心律失常，在改善室颤患者的生存率方面具有显着的益处。然而,它的长期使用会带来严重的不良影响，包括甲状腺功能障碍,肝损伤,和肺毒性，需要仔细监测和管理。尽管它的功效,需要研究早期发现和管理胺碘酮的副作用是至关重要的，强调定期监测和可能调整治疗以减轻这些风险的重要性。
