Abstract：
OBJECTIVE: Management of primary healthcare and routine minor procedures for children with autism spectrum disorder (ASD) can be challenging; therefore, when behavioural strategies fail, sedative medications are often employed. We evaluated the effectiveness of the current pharmacological strategies for managing children with ASD.
METHODS: We performed a systematic review and meta-analysis of the current approaches for procedural sedation in children with ASD.
RESULTS: Twenty studies met inclusion criteria. Dexmedetomidine, midazolam, propofol and chloral hydrate were the most efficient agents for successful procedures, while propofol had the highest number of adverse events. The most frequently used agents were dexmedetomidine and midazolam or a combination of the two, and the effectiveness of dexmedetomidine plus midazolam was superior to dexmedetomidine alone.
CONCLUSIONS: Multiple effective drug regimens exist for procedural sedation in children with ASD. These results could support the development of specific guidelines for procedural sedation in children with ASD.
METHODS: We performed a systematic review and meta-analysis of the current approaches for procedural sedation in children with ASD.
RESULTS: Twenty studies met inclusion criteria. Dexmedetomidine, midazolam, propofol and chloral hydrate were the most efficient agents for successful procedures, while propofol had the highest number of adverse events. The most frequently used agents were dexmedetomidine and midazolam or a combination of the two, and the effectiveness of dexmedetomidine plus midazolam was superior to dexmedetomidine alone.
CONCLUSIONS: Multiple effective drug regimens exist for procedural sedation in children with ASD. These results could support the development of specific guidelines for procedural sedation in children with ASD.
摘要：
目的：针对自闭症谱系障碍（ASD）儿童的初级医疗保健和常规次要程序的管理可能具有挑战性；因此，当行为策略失败时，经常使用镇静药物。我们评估了当前治疗ASD儿童的药物策略的有效性。
方法：我们对ASD患儿目前的程序性镇静方法进行了系统评价和荟萃分析。
结果：20项研究符合纳入标准。右美托咪定,咪达唑仑,异丙酚和水合氯醛是成功手术的最有效药物，而异丙酚的不良事件最多。最常用的药物是右美托咪定和咪达唑仑或两者的组合，右美托咪定联合咪达唑仑的疗效优于单用右美托咪定.
结论：ASD患儿存在多种有效的程序性镇静药物方案。这些结果可以支持制定ASD儿童程序性镇静的具体指南。
方法：我们对ASD患儿目前的程序性镇静方法进行了系统评价和荟萃分析。
结果：20项研究符合纳入标准。右美托咪定,咪达唑仑,异丙酚和水合氯醛是成功手术的最有效药物，而异丙酚的不良事件最多。最常用的药物是右美托咪定和咪达唑仑或两者的组合，右美托咪定联合咪达唑仑的疗效优于单用右美托咪定.
结论：ASD患儿存在多种有效的程序性镇静药物方案。这些结果可以支持制定ASD儿童程序性镇静的具体指南。
