METHODS: A retrospective review was performed of patients with FP consultation due to an increased risk of iatrogenic infertility at Ann & Robert H. Lurie Children\'s Hospital of Chicago from 2018 to 2022. Data on diagnosis, age, treatment characteristics, and procedure were collected.
RESULTS: A total of 337 patients (n = 149 with ovaries, n = 188 with testes) had an FP consultation. Of patients with ovaries, 106 (71.1%) underwent ovarian tissue cryopreservation (OTC), 10 (6.7%) completed ovarian stimulation/egg retrieval (OSER), and 33 (22.1%) declined FP. Of the patients with testes, 98 (52.1%) underwent testicular tissue cryopreservation (TTC), 48 (25.5%) completed sperm banking (SB), and 42 (22.3%) declined FP. Median time from referral to FP consultation was short (ovaries: 2 days, range: 0-6; testes: 1 day, range: 0-5). OSER had a significantly longer RTT versus OTC and no FP (52.5 vs.19.5 vs. 12 days, p = .01). SB had a significantly quicker RTT compared to TTC or no FP (9.0 vs. 21.0 vs. 13.5 days; p = .008). For patients who underwent OTC/TTC and those who declined FP, there was no significant difference in time from consultation to treatment.
CONCLUSIONS: It is feasible to promptly offer and complete FP with minimal delay to disease-directed treatment.
方法:对2018年至2022年在芝加哥Ann&RobertH.Lurie儿童医院因医源性不孕症风险增加而进行FP咨询的患者进行了回顾性研究。诊断数据,年龄,治疗特点,和程序被收集。
结果:共337例患者(n=149例卵巢,n=188,有睾丸)进行了FP咨询。卵巢患者,106例(71.1%)卵巢组织冷冻保存(OTC),10(6.7%)完成卵巢刺激/取卵(OSER),33人(22.1%)下降FP。在有睾丸的患者中,98例(52.1%)接受了睾丸组织冷冻保存(TTC),48(25.5%)完成精子银行(SB),42人(22.3%)下降FP。从转诊到FP会诊的中位时间很短(卵巢:2天,范围:0-6;睾丸:1天,范围:0-5)。与OTC相比,OSER的RTT明显更长,并且没有FP(52.5vs.19.5vs.12天,p=.01)。与TTC或无FP相比,SB的RTT明显更快(9.0vs.21.0vs.13.5天;p=.008)。对于接受OTC/TTC和拒绝FP的患者,从咨询到治疗的时间没有显着差异。
结论:及时提供并完成FP是可行的,而对疾病定向治疗的延迟最小。