METHODS: 29 children with DRE were randomized to experimental (EG) and control (CG) groups. To encourage PE, the EG performed one hour of aerobic activity three days a week for six months, outside the school setting. Compliance was monitored using activity wristbands, with data reported weekly by parents. Health-related quality of life (HRQoL), seizure frequency, physical activity (PA), physical fitness (musculoskeletal, motor, and Cardiorespiratory Fitness), and body composition, were assessed at baseline, at three and six months.
RESULTS: Seizure frequency in the last six months evolved from 10.5 seizures/week at baseline, to 4.5 at the end of the study in the EG, and from 5.2 seizures/week to one in the CG. Significant differences were found in weekly hours-PE (η2= 0.49); motor fitness (η2= 0.08); Cardiorespiratory Fitness (η2= 0.19); weight (η2= 0.003); Triceps skinfold thickness (η2= 0.05); lower limb muscular strength (η2= 0.03); HRQoL (η2= 0.02); and PA (η2= 0.22). Post-hoc ANOVA revealed that EG improved significantly (p < 0.05) between baseline and six months. Negative correlations were observed between PA and seizure frequency.
CONCLUSIONS: Supported by WT, children with DRE increased the weekly hours of PE at three and six months, with no increase in seizure frequency. Our study provides evidence of the effectiveness of PE for improving HRQoL.
方法:29名DRE患儿随机分为实验组(EG)和对照组(CG)。为了鼓励体育,EG每周三天进行一小时的有氧活动,持续六个月,在学校环境之外。使用活动腕带监控合规性,父母每周报告的数据。健康相关生活质量(HRQoL),癫痫发作频率,身体活动(PA),身体健康(肌肉骨骼,电机,和心肺健身),和身体组成,在基线评估,在三个月和六个月。
结果:过去六个月的癫痫发作频率从基线时的10.5次癫痫发作/周演变而来,到4.5在EG研究结束时,从5.2次癫痫发作/周增加到1次。每周小时PE(η2=0.49);运动健身(η2=0.08);心肺健身(η2=0.19);体重(η2=0.003);肱三头肌皮褶厚度(η2=0.05);下肢肌肉力量(η2=0.03);HRQoL(η2=0.02);和PA(η2=0.22)。事后方差分析显示,EG在基线和6个月之间显著改善(p<0.05)。PA与癫痫发作频率呈负相关。
结论:由WT支持,患有DRE的儿童在三个月和六个月时增加了每周的PE时间,癫痫发作频率没有增加。我们的研究提供了PE改善HRQoL的有效性的证据。