Abstract：
OBJECTIVE: Using data from the National Health Interview Survey (NHIS), this study examined the odds of functional limitations across nine domains by cancer status (with vs. without cancer history) and age group (18-44, 45-64, 65 + years).
METHODS: Participants were 151,509 adults in the 2014-2018 NHIS. Functional limitations included self-reported difficulty conducting nine activities. Data were analyzed using age-stratified multivariate logistic regression (no limitation vs. limited in any way; minor limitation vs. major limitation) and are reported as covariate-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). To gather insight on the influence of cancer, compared to aging without a history of cancer, on functional limitations, we also conducted exploratory regression analyses comparing all cancer by age groups to 18-44 year-olds without a cancer history.
RESULTS: Cancer survivors (n = 12,518) were more likely to report a limitation than adults without cancer (n = 138,991). Age-stratified ORs for 1 + limitation were 2.75 (95% CI 1.98, 3.81) among 18-44 year-olds, 2.42 (95% CI 2.00, 2.93) among 45-64 year-olds, and 1.59 (95% CI 1.39, 1.82) among 65 + year-olds. Cancer survivors were more likely to report major limitations across multiple domains, with age-stratified ORs ranging from 1.18 (65 + year-olds, stooping limitation) to 2.28 (18-44 year-old, sitting limitation). ORs from exploratory analyses were lowest among 45-64 year-old adults without a cancer history (2.69-4.42) and highest among older adult cancer survivors (3.42-14.73).
CONCLUSIONS: Cancer was associated with limitations across age groups, with the highest age-stratified ORs observed among younger adults and for mobility and lower-extremity limitations. Stronger efforts to assess limitations as part of routine care and implement targeted interventions to address limitations are needed.
CONCLUSIONS: Functional limitations have been linked with poorer aging trajectories and lower quality of life in cancer and non-cancer populations. Routine screening to identify and discuss functional limitations with cancer patients may help reduce the burden of such limitations on survivors.
METHODS: Participants were 151,509 adults in the 2014-2018 NHIS. Functional limitations included self-reported difficulty conducting nine activities. Data were analyzed using age-stratified multivariate logistic regression (no limitation vs. limited in any way; minor limitation vs. major limitation) and are reported as covariate-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). To gather insight on the influence of cancer, compared to aging without a history of cancer, on functional limitations, we also conducted exploratory regression analyses comparing all cancer by age groups to 18-44 year-olds without a cancer history.
RESULTS: Cancer survivors (n = 12,518) were more likely to report a limitation than adults without cancer (n = 138,991). Age-stratified ORs for 1 + limitation were 2.75 (95% CI 1.98, 3.81) among 18-44 year-olds, 2.42 (95% CI 2.00, 2.93) among 45-64 year-olds, and 1.59 (95% CI 1.39, 1.82) among 65 + year-olds. Cancer survivors were more likely to report major limitations across multiple domains, with age-stratified ORs ranging from 1.18 (65 + year-olds, stooping limitation) to 2.28 (18-44 year-old, sitting limitation). ORs from exploratory analyses were lowest among 45-64 year-old adults without a cancer history (2.69-4.42) and highest among older adult cancer survivors (3.42-14.73).
CONCLUSIONS: Cancer was associated with limitations across age groups, with the highest age-stratified ORs observed among younger adults and for mobility and lower-extremity limitations. Stronger efforts to assess limitations as part of routine care and implement targeted interventions to address limitations are needed.
CONCLUSIONS: Functional limitations have been linked with poorer aging trajectories and lower quality of life in cancer and non-cancer populations. Routine screening to identify and discuss functional limitations with cancer patients may help reduce the burden of such limitations on survivors.
摘要：
目标：使用来自国家健康访谈调查（NHIS）的数据，这项研究检查了按癌症状态划分的9个领域的功能限制的几率(与无癌症史）和年龄组（18-44，45-64，65岁以上）。
方法：在2014-2018年NHIS中，参与者为151,509名成年人。功能限制包括自我报告的九项活动的困难。使用年龄分层多变量逻辑回归分析数据(无限制与以任何方式限制；轻微限制vs.主要限制)，并报告为协变量调整比值比(OR)和95%置信区间(95%CIs)。为了了解癌症的影响，与没有癌症史的衰老相比，关于功能限制，我们还进行了探索性回归分析,比较了按年龄组划分的所有癌症与没有癌症病史的18-44岁人群.
结果：癌症幸存者（n=12,518）比没有癌症的成年人（n=138,991）更有可能报告限制。在18-44岁的人群中，1+限制的年龄分层OR为2.75(95%CI1.98，3.81)，45-64岁人群中的2.42（95%CI2.00，2.93），65岁以上人群中的1.59（95%CI1.39，1.82）。癌症幸存者更有可能报告多个领域的主要限制，年龄分层的OR范围为1.18(65岁以上的人，弯腰限制)到2.28(18-44岁，坐位限制)。探索性分析的ORs在45-64岁无癌症病史的成年人中最低（2.69-4.42），在老年癌症幸存者中最高（3.42-14.73）。
结论：癌症与各年龄组的局限性有关，在年轻人中观察到最高的年龄分层OR，以及活动能力和下肢限制。作为常规护理的一部分，需要更加努力地评估局限性，并实施有针对性的干预措施来解决局限性。
结论：在癌症和非癌症人群中，功能限制与较差的衰老轨迹和较低的生活质量有关。常规筛查以确定和讨论癌症患者的功能限制可能有助于减轻幸存者的这种限制的负担。
方法：在2014-2018年NHIS中，参与者为151,509名成年人。功能限制包括自我报告的九项活动的困难。使用年龄分层多变量逻辑回归分析数据(无限制与以任何方式限制；轻微限制vs.主要限制)，并报告为协变量调整比值比(OR)和95%置信区间(95%CIs)。为了了解癌症的影响，与没有癌症史的衰老相比，关于功能限制，我们还进行了探索性回归分析,比较了按年龄组划分的所有癌症与没有癌症病史的18-44岁人群.
结果：癌症幸存者（n=12,518）比没有癌症的成年人（n=138,991）更有可能报告限制。在18-44岁的人群中，1+限制的年龄分层OR为2.75(95%CI1.98，3.81)，45-64岁人群中的2.42（95%CI2.00，2.93），65岁以上人群中的1.59（95%CI1.39，1.82）。癌症幸存者更有可能报告多个领域的主要限制，年龄分层的OR范围为1.18(65岁以上的人，弯腰限制)到2.28(18-44岁，坐位限制)。探索性分析的ORs在45-64岁无癌症病史的成年人中最低（2.69-4.42），在老年癌症幸存者中最高（3.42-14.73）。
结论：癌症与各年龄组的局限性有关，在年轻人中观察到最高的年龄分层OR，以及活动能力和下肢限制。作为常规护理的一部分，需要更加努力地评估局限性，并实施有针对性的干预措施来解决局限性。
结论：在癌症和非癌症人群中，功能限制与较差的衰老轨迹和较低的生活质量有关。常规筛查以确定和讨论癌症患者的功能限制可能有助于减轻幸存者的这种限制的负担。
