Abstract：
OBJECTIVE: To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.
METHODS: A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
RESULTS: 177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.
CONCLUSIONS: Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
METHODS: A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
RESULTS: 177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.
CONCLUSIONS: Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
摘要：
目的：强调眼前和眼血管循环动力学对有和无心血管危险因素（CVR）患者视网膜毛细血管丛（RCP）和脉络膜毛细血管（CC）血管密度（VD）的影响。
方法：一项针对有和没有CVR因素（1型和2型糖尿病，动脉高血压,和高胆固醇血症）。荧光素（FA）和吲哚菁（ICGA）血管造影循环时间分别为动脉时间（FAAT），层流的开始(FAstartLF)和结束(FAendLF),和动脉时间（ICGAAT），分别。OCT血管造影VDs为浅表(VDSCP)和深(VDDCP)RCP和CC(VDCC)VDs。校正混杂因素后进行相关和回归分析。
结果：177例患者的177只眼（平均年龄：65.2±15.9岁，包括有CVR的n=92和无CVR的n=85）。VDSCP和VDDCP与FAAT呈显著负相关,FastartLF和FAendLF同样具有ICGAAT的VDCC。无CVR患者的相关性强于有CVR患者。CVR,FAAT,FastartLF和FAendLF与VDCP的相关性高于VDSCP。FAAT,FAstartLF和FAendLF显著影响VDSCP和VDDCP,同样，ICGAAT也影响了VDDCP。VDDCP受FAAT和FastartLF影响最大。
结论：眼部和眼前循环动力学显著影响RCP和CCVDs，尤其是深RCP.
方法：一项针对有和没有CVR因素（1型和2型糖尿病，动脉高血压,和高胆固醇血症）。荧光素（FA）和吲哚菁（ICGA）血管造影循环时间分别为动脉时间（FAAT），层流的开始(FAstartLF)和结束(FAendLF),和动脉时间（ICGAAT），分别。OCT血管造影VDs为浅表(VDSCP)和深(VDDCP)RCP和CC(VDCC)VDs。校正混杂因素后进行相关和回归分析。
结果：177例患者的177只眼（平均年龄：65.2±15.9岁，包括有CVR的n=92和无CVR的n=85）。VDSCP和VDDCP与FAAT呈显著负相关,FastartLF和FAendLF同样具有ICGAAT的VDCC。无CVR患者的相关性强于有CVR患者。CVR,FAAT,FastartLF和FAendLF与VDCP的相关性高于VDSCP。FAAT,FAstartLF和FAendLF显著影响VDSCP和VDDCP,同样，ICGAAT也影响了VDDCP。VDDCP受FAAT和FastartLF影响最大。
结论：眼部和眼前循环动力学显著影响RCP和CCVDs，尤其是深RCP.
