%0 Journal Article
%T Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.
%A Vallée R
%A Körpe D
%A Vallée JN
%A Tsiropoulos GN
%A Gallo Castro D
%A Mantel I
%A Pournaras CJ
%A Ambresin A
%J Graefes Arch Clin Exp Ophthalmol
%V 0
%N 0
%D 2024 Jul 31
%M 39083077
%F 3.535
%R 10.1007/s00417-024-06544-4
%X <B>OBJECTIVE: </B>To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.<BR><B>METHODS: </B>A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FAAT), start (FAstartLF) and end (FAendLF) of laminar flow, and arterial time (ICGAAT), respectively. OCT angiography VDs were superficial (VDSCP) and deep (VDDCP) RCPs and CC (VDCC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.<BR><B>RESULTS: </B>177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VDSCP and VDDCP were significantly inversely correlated with FAAT, FAstartLF and FAendLF likewise VDCC with ICGAAT. Correlations were stronger in patients without CVR than with CVR. CVR, FAAT, FAstartLF and FAendLF were more strongly correlated with VDDCP than VDSCP. FAAT, FAstartLF and FAendLF significantly impacted VDSCP and VDDCP, likewise ICGAAT impacted VDDCP. VDDCP was most strongly impacted by FAAT and FAstartLF.<BR><B>CONCLUSIONS: </B>Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.