Abstract：
Stroke is a prominent contributor to mortality and impairment on a global scale. Ischemic stroke accounts for approximately 80% of stroke cases and is caused by occlusion of cerebral blood vessels. Enhancing neurogenesis through the modulation of the neural stem cell niche in the adult brain is a promising therapeutic strategy for individuals afflicted with ischemic stroke. Neurogenesis results in the generation of newborn neurons that serve as replacements for deceased neural cells within the ischemic core, thereby playing a significant role in the process of neural restoration subsequent to cerebral ischemia. Research has shown that activation of the Wnt/β-catenin pathway can augment neurogenesis following cerebral ischemia, suggesting that this pathway is a potentially beneficial therapeutic target for managing ischemic stroke. This review provides an extensive analysis of the current knowledge regarding the involvement of the Wnt/β-catenin pathway in promoting neurogenesis, thereby offering a promising avenue for therapeutic intervention in the context of ischemic stroke or other neurological impairments.
摘要：
在全球范围内，中风是死亡率和损害的主要原因。缺血性中风约占中风病例的80％，是由脑血管阻塞引起的。通过调节成人大脑中的神经干细胞小生境来增强神经发生是患有缺血性中风的个体的有希望的治疗策略。神经发生导致新生神经元的产生，作为缺血核心内死亡神经细胞的替代，从而在脑缺血后的神经恢复过程中发挥重要作用。研究表明，Wnt/β-catenin通路的激活可以增强脑缺血后的神经发生，提示该通路是治疗缺血性卒中的潜在有益治疗靶点.这篇综述提供了关于Wnt/β-catenin通路参与促进神经发生的现有知识的广泛分析。从而为缺血性中风或其他神经损伤的背景下的治疗干预提供了有希望的途径。
