Abstract：
OBJECTIVE: The purpose of this study was to examine relationship between anhedonia, disruption of biological rhythms, functioning and depression severity in patients with bipolar disorder (BD).
METHODS: The sample included 58 patients with bipolar depression aged 18-65 years. The participants were assessed using the following scales: Dimensional Anhedonia Rating Scale (DARS), Snaith-Hamilton Pleasure Scale (SHAPS), Quick Inventory of Depressive Symptomatology- self-report (QIDS-SR), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Functioning Assessment Short Test (FAST). Correlations between the variables were calculated. We built linear regression models with FAST or QIDS-SR as a dependent variable. Mediation analysis was performed.
RESULTS: Statistically significant correlations were observed between the included variables. Biological rhythms dysregulation and anhedonia were independent predictors of the level of functioning or depression severity. Mediation analysis demonstrated statistically significant mediation of the relationship between anhedonia and depression severity/functioning by the BRIAN score.
CONCLUSIONS: We demonstrated for the first time the interactions between anhedonia, dysregulation of biological rhythms and functioning/depression severity in patients with BD. Reward deficits by causing disruption of rhythm of daily activities and social contacts may result in more difficulties in functioning and higher intensity of depressive symptoms.
METHODS: The sample included 58 patients with bipolar depression aged 18-65 years. The participants were assessed using the following scales: Dimensional Anhedonia Rating Scale (DARS), Snaith-Hamilton Pleasure Scale (SHAPS), Quick Inventory of Depressive Symptomatology- self-report (QIDS-SR), Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), Functioning Assessment Short Test (FAST). Correlations between the variables were calculated. We built linear regression models with FAST or QIDS-SR as a dependent variable. Mediation analysis was performed.
RESULTS: Statistically significant correlations were observed between the included variables. Biological rhythms dysregulation and anhedonia were independent predictors of the level of functioning or depression severity. Mediation analysis demonstrated statistically significant mediation of the relationship between anhedonia and depression severity/functioning by the BRIAN score.
CONCLUSIONS: We demonstrated for the first time the interactions between anhedonia, dysregulation of biological rhythms and functioning/depression severity in patients with BD. Reward deficits by causing disruption of rhythm of daily activities and social contacts may result in more difficulties in functioning and higher intensity of depressive symptoms.
摘要：
目的：本研究的目的是检查快感缺失与破坏生物节律，双相情感障碍（BD）患者的功能和抑郁严重程度。
方法：样本包括58名年龄在18-65岁的双相抑郁患者。参与者使用以下量表进行评估：维度快感评分量表（DARS），Snaith-Hamilton快乐量表（SHAPS），抑郁症状快速清单-自我报告(QIDS-SR)，神经精神病学评估的生物节律访谈（BRIAN），功能评估短期测试(FAST)。计算变量之间的相关性。我们建立了以FAST或QIDS-SR为因变量的线性回归模型。进行中介分析。
结果：在所包括的变量之间观察到统计学上显著的相关性。生物节律失调和快感缺乏是功能水平或抑郁严重程度的独立预测因素。中介分析表明，通过BRIAN评分，快感缺失与抑郁严重程度/功能之间的关系具有统计学意义。
结论：我们首次证明了快感缺失之间的相互作用，BD患者的生物节律和功能/抑郁严重程度的失调。通过破坏日常活动和社会接触的节奏而导致的奖励不足可能导致更多的功能困难和更高强度的抑郁症状。
方法：样本包括58名年龄在18-65岁的双相抑郁患者。参与者使用以下量表进行评估：维度快感评分量表（DARS），Snaith-Hamilton快乐量表（SHAPS），抑郁症状快速清单-自我报告(QIDS-SR)，神经精神病学评估的生物节律访谈（BRIAN），功能评估短期测试(FAST)。计算变量之间的相关性。我们建立了以FAST或QIDS-SR为因变量的线性回归模型。进行中介分析。
结果：在所包括的变量之间观察到统计学上显著的相关性。生物节律失调和快感缺乏是功能水平或抑郁严重程度的独立预测因素。中介分析表明，通过BRIAN评分，快感缺失与抑郁严重程度/功能之间的关系具有统计学意义。
结论：我们首次证明了快感缺失之间的相互作用，BD患者的生物节律和功能/抑郁严重程度的失调。通过破坏日常活动和社会接触的节奏而导致的奖励不足可能导致更多的功能困难和更高强度的抑郁症状。
