PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the potential causal association between COVID-19 exposure and optic nerve and visual pathway disorders through a two-sample bidirectional Mendelian randomization (MR) analysis, and to provide empirical support for the lung-brain axis.
UNASSIGNED: This MR analysis utilized publicly accessible summary-level data from genome-wide association studies on COVID-19 (n=158,783) and optic nerve and visual pathway diseases (n=412,181), primarily involving individuals of European descent. The random-effect inverse-variance weighted estimation was applied as the main analytical approach, complemented by MR-Egger, weighted median, and weighted mode methods. The heterogeneity and pleiotropy of the instrumental variables were assessed using Cochran\'s Q test, leave-one-out sensitivity analysis, MR-Egger intercept test, MR-PRESSO, and funnel plot evaluations.
UNASSIGNED: In the forward analysis, the inverse-variance weighted method identified a significant causal effect of COVID-19 on optic nerve and visual pathway disorders (odds ratio = 1.697, 95% confidence interval: 1.086-2.652, p = 0.020). Directionally consistent results were also observed with MR-Egger regression, weighted median, and weighted mode approaches. Conversely, the reverse analysis revealed no causal effects of optic nerve and visual pathway disorders on COVID-19 susceptibility.
UNASSIGNED: Our findings suggest that COVID-19 exposure may increase the risk of developing optic nerve and visual pathway disorders, supporting the lung-brain axis hypothesis. These results underscore the importance of vigilant monitoring of the visual system in patients recovering from COVID-19 and suggest potential avenues for future therapeutic strategies.
UNASSIGNED: This MR analysis utilized publicly accessible summary-level data from genome-wide association studies on COVID-19 (n=158,783) and optic nerve and visual pathway diseases (n=412,181), primarily involving individuals of European descent. The random-effect inverse-variance weighted estimation was applied as the main analytical approach, complemented by MR-Egger, weighted median, and weighted mode methods. The heterogeneity and pleiotropy of the instrumental variables were assessed using Cochran\'s Q test, leave-one-out sensitivity analysis, MR-Egger intercept test, MR-PRESSO, and funnel plot evaluations.
UNASSIGNED: In the forward analysis, the inverse-variance weighted method identified a significant causal effect of COVID-19 on optic nerve and visual pathway disorders (odds ratio = 1.697, 95% confidence interval: 1.086-2.652, p = 0.020). Directionally consistent results were also observed with MR-Egger regression, weighted median, and weighted mode approaches. Conversely, the reverse analysis revealed no causal effects of optic nerve and visual pathway disorders on COVID-19 susceptibility.
UNASSIGNED: Our findings suggest that COVID-19 exposure may increase the risk of developing optic nerve and visual pathway disorders, supporting the lung-brain axis hypothesis. These results underscore the importance of vigilant monitoring of the visual system in patients recovering from COVID-19 and suggest potential avenues for future therapeutic strategies.
摘要：
■通过双样本双向孟德尔随机化（MR）分析，研究COVID-19暴露与视神经和视觉通路障碍之间的潜在因果关系，并为肺脑轴提供经验支持。
■这项MR分析利用了来自COVID-19（n=158,783）和视神经和视觉通路疾病（n=412,181）的全基因组关联研究的公开汇总数据，主要涉及欧洲血统的个人。随机效应逆方差加权估计作为主要分析方法，由MR-Egger补充，加权中位数，和加权模式方法。使用Cochran的Q检验评估工具变量的异质性和多效性。留一法敏感性分析，MR-Egger截距测试,MR-PRESSO,和漏斗图评估。
■在正向分析中，逆方差加权方法确定了COVID-19对视神经和视觉通路障碍的显著因果效应(比值比=1.697,95%置信区间:1.086-2.652,p=0.020).MR-Egger回归也观察到方向一致的结果，加权中位数，和加权模式方法。相反，反向分析显示,视神经和视觉通路障碍对COVID-19易感性无因果关系.
我们的研究结果表明，暴露COVID-19可能会增加发生视神经和视觉通路障碍的风险，支持肺脑轴假说。这些结果强调了警惕监测COVID-19康复患者视觉系统的重要性，并为未来的治疗策略提供了潜在的途径。
■这项MR分析利用了来自COVID-19（n=158,783）和视神经和视觉通路疾病（n=412,181）的全基因组关联研究的公开汇总数据，主要涉及欧洲血统的个人。随机效应逆方差加权估计作为主要分析方法，由MR-Egger补充，加权中位数，和加权模式方法。使用Cochran的Q检验评估工具变量的异质性和多效性。留一法敏感性分析，MR-Egger截距测试,MR-PRESSO,和漏斗图评估。
■在正向分析中，逆方差加权方法确定了COVID-19对视神经和视觉通路障碍的显著因果效应(比值比=1.697,95%置信区间:1.086-2.652,p=0.020).MR-Egger回归也观察到方向一致的结果，加权中位数，和加权模式方法。相反，反向分析显示,视神经和视觉通路障碍对COVID-19易感性无因果关系.
我们的研究结果表明，暴露COVID-19可能会增加发生视神经和视觉通路障碍的风险，支持肺脑轴假说。这些结果强调了警惕监测COVID-19康复患者视觉系统的重要性，并为未来的治疗策略提供了潜在的途径。
