PDF(Pubmed)
Abstract：
OBJECTIVE: Transsphenoidal surgery for lactotroph pituitary neuroendocrine tumor (PitNET) lowers serum prolactin concentrations, occasionally below the normal range. However, the clinical significance of postoperative hypoprolactinemia is still unclear. In this study, we retrospectively reviewed the female patients with lactotroph PitNET who were treated with transsphenoidal surgery to elucidate the influence of postoperative hypoprolactinemia on regular menstruation restoration and endocrinological remission.
RESULTS: The serum prolactin levels in all thirty three participating females had decreased following surgery. Serum prolactin levels in seven patients had decreased below the lower limit of normal ranges (hypoproactinemia group) and in the remaining twenty six patients, it was within the normal range (non-hypoproractinemia group). In hypoprolactinemia group, regular menstruation was restored in all patients with only lactotroph axis deficiency. Nine patients from the non-hypoprolactinemia group experienced re-elevation of serum prolactin concentration (27%). No patient in hypoprolactinemia group experienced the relapse of hyperprolactinemia. These data suggest that early postoperative hypoprolactinemia after transsphenoidal surgery for lactotroph PitNET is not only a good predictive factor for endocrinological remission but also no unfavorable effects on regular menstruation restoration.
RESULTS: The serum prolactin levels in all thirty three participating females had decreased following surgery. Serum prolactin levels in seven patients had decreased below the lower limit of normal ranges (hypoproactinemia group) and in the remaining twenty six patients, it was within the normal range (non-hypoproractinemia group). In hypoprolactinemia group, regular menstruation was restored in all patients with only lactotroph axis deficiency. Nine patients from the non-hypoprolactinemia group experienced re-elevation of serum prolactin concentration (27%). No patient in hypoprolactinemia group experienced the relapse of hyperprolactinemia. These data suggest that early postoperative hypoprolactinemia after transsphenoidal surgery for lactotroph PitNET is not only a good predictive factor for endocrinological remission but also no unfavorable effects on regular menstruation restoration.
摘要：
目的：经蝶手术治疗催乳垂体神经内分泌肿瘤（PitNET）可降低血清催乳素浓度，偶尔低于正常范围。然而,术后低泌乳素血症的临床意义尚不清楚。在这项研究中,我们回顾性回顾了经蝶入路手术治疗的催乳素PitNET女性患者，以阐明术后低泌乳素血症对月经正常恢复和内分泌缓解的影响。
结果：所有33名参与女性的血清催乳素水平在手术后均下降。7例患者的血清催乳素水平下降到正常范围的下限以下（低泌乳素血症组），其余26例患者，在正常范围内(非低放线血症组).在低泌乳素血症组中，所有仅催乳轴不足的患者均恢复了正常月经。非低泌乳素血症组的9例患者血清泌乳素浓度再次升高（27％）。低泌乳素血症组没有患者出现高泌乳素血症复发。这些数据表明，经蝶窦手术用于催乳PitNET的术后早期低泌乳素血症不仅是内分泌缓解的良好预测因素，而且对月经正常恢复没有不利影响。
结果：所有33名参与女性的血清催乳素水平在手术后均下降。7例患者的血清催乳素水平下降到正常范围的下限以下（低泌乳素血症组），其余26例患者，在正常范围内(非低放线血症组).在低泌乳素血症组中，所有仅催乳轴不足的患者均恢复了正常月经。非低泌乳素血症组的9例患者血清泌乳素浓度再次升高（27％）。低泌乳素血症组没有患者出现高泌乳素血症复发。这些数据表明，经蝶窦手术用于催乳PitNET的术后早期低泌乳素血症不仅是内分泌缓解的良好预测因素，而且对月经正常恢复没有不利影响。
