PDF(Pubmed)
Abstract：
Creativity and mental disorders are sometimes seen as intertwined, but research is still unclear on whether, how much, and why. Here we explore the potential role of shared genetic factors behind creativity and symptoms of borderline personality disorder (BPD, characterized by mood swings and randomness of thoughts). Data were collected from 6745 twins (2378 complete pairs) by the Netherlands Twin Register on BPD scores (PAI-BOR questionnaire) and working in a creative profession (proxy for creativity). First, we tested whether there is an association between BPD symptoms and creative professions. Results confirmed that individuals scoring higher on the BPD spectrum are more likely to have a creative profession (Cohen\'s d = 0.16). Next, we modeled how much of this association reflects underlying genetic and/or environmental correlations-by using a bivariate classical twin design. We found that creativity and BPD were each influenced by genetic factors (heritability = 0.45 for BPD and 0.67 for creativity) and that these traits are genetically correlated rG = 0.17. Environmental influences were not correlated. This is evidence for a common genetic mechanism between borderline personality scores and creativity which may reflect causal effects and shed light on mechanisms.
摘要：
创造力和精神障碍有时被视为交织在一起，但是研究还不清楚是否，多少,以及为什么。在这里，我们探讨了共同的遗传因素在创造力和边缘性人格障碍症状背后的潜在作用(BPD，以情绪波动和思想随机性为特征)。荷兰双胞胎登记册从6745对双胞胎（2378对完整的双胞胎）中收集了BPD分数（PAI-BOR问卷）和从事创造性职业（创造力代理）的数据。首先,我们测试了BPD症状与创造性职业之间是否存在关联.结果证实，在BPD频谱上得分较高的个体更有可能拥有创造性职业（Cohen'sd=0.16）。接下来,我们通过使用双变量经典孪生设计,模拟了这种关联在多大程度上反映了潜在的遗传和/或环境相关性.我们发现创造力和BPD均受遗传因素的影响（BPD的遗传力=0.45，创造力为0.67），并且这些性状与rG=0.17遗传相关。环境影响不相关。这是边缘人格得分和创造力之间共同遗传机制的证据，该机制可能反映因果效应并阐明机制。
