Abstract：
Anhedonia and depressed mood are two cardinal symptoms of major depressive disorder (MDD). Prior work has demonstrated that cannabis consumers often endorse anhedonia and depressed mood, which may contribute to greater cannabis use (CU) over time. However, it is unclear (1) how the unique influence of anhedonia and depressed mood affect CU and (2) how these symptoms predict CU over more proximal periods of time, including the next day or week (rather than proceeding weeks or months). The current study used data collected from ecological momentary assessment (EMA) in a sample with MDD (N = 55) and employed mixed effects models to detect and predict weekly and daily CU from anhedonia and depressed mood over 90 days. Results indicated that anhedonia and depressed mood were significantly associated with CU, yet varied at daily and weekly scales. Moreover, these associations varied in both strength and directionality. In weekly models, less anhedonia and greater depressed mood were associated with greater CU, and directionality of associations were reversed in the models looking at any CU (compared to none). Findings provide evidence that anhedonia and depressed mood demonstrate complex associations with CU and emphasize leveraging EMA-based studies to understand these associations with more fine-grained detail.
摘要：
快感和情绪低落是重度抑郁症（MDD）的两个主要症状。先前的工作表明，大麻消费者经常认可快感和抑郁情绪，随着时间的推移，这可能会导致更多的大麻使用(CU)。然而,尚不清楚（1）快感缺失和抑郁情绪的独特影响如何影响CU，以及（2）这些症状如何在更近的时间段内预测CU，包括下一天或下一周（而不是继续数周或数月）。当前的研究使用了从具有MDD（N=55）的样本中的生态瞬时评估（EMA）中收集的数据，并采用了混合效应模型来检测和预测90天内的不良情绪和抑郁情绪中的每周和每日CU。结果表明，快感缺失和抑郁情绪与CU显著相关，但在每日和每周尺度上有所不同。此外，这些关联在强度和方向性上都有所不同。在每周模型中，快感减少和抑郁情绪增加与CU增加相关，在观察任何CU(与无CU相比)的模型中,关联的方向性逆转.研究结果提供了证据，表明快感和抑郁情绪与CU表现出复杂的关联，并强调利用基于EMA的研究以更细粒度的细节来理解这些关联。
