Abstract：
OBJECTIVE: The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection.
METHODS: Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan-Meier method.
RESULTS: A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (P = 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (P = 0.216).
CONCLUSIONS: Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.
METHODS: Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan-Meier method.
RESULTS: A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (P = 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (P = 0.216).
CONCLUSIONS: Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.
摘要：
目的：术后胆漏对肝癌肝切除术患者预后的影响存在争议。本研究旨在探讨胆漏对肝细胞癌患者肝切除术后预后的影响。
方法：纳入2009年至2019年在神户大学医院和兵库癌症中心接受肝切除术的肝细胞癌患者。胆漏组和无胆漏组之间的倾向评分匹配后，使用Kaplan-Meier方法评估5年无复发生存率和总生存率的差异.
结果：共有781名患者，包括43例术后胆漏,进行了分析。在匹配的队列中，每组40例。胆漏组和无胆漏组肝切除术后5年无复发生存率分别为35%和32%,分别(P=0.857)。胆漏组和无胆漏组的5年总生存率分别为44%和54%，分别为(P=0.216)。
结论：总体而言，胆漏可能不会对接受肝切除术的肝细胞癌患者的预后产生深远的负面影响。
方法：纳入2009年至2019年在神户大学医院和兵库癌症中心接受肝切除术的肝细胞癌患者。胆漏组和无胆漏组之间的倾向评分匹配后，使用Kaplan-Meier方法评估5年无复发生存率和总生存率的差异.
结果：共有781名患者，包括43例术后胆漏,进行了分析。在匹配的队列中，每组40例。胆漏组和无胆漏组肝切除术后5年无复发生存率分别为35%和32%,分别(P=0.857)。胆漏组和无胆漏组的5年总生存率分别为44%和54%，分别为(P=0.216)。
结论：总体而言，胆漏可能不会对接受肝切除术的肝细胞癌患者的预后产生深远的负面影响。
