Abstract：
BACKGROUND: 10-year atherosclerotic cardiovascular disease (ASCVD) risk scores were useful for predicting large vessel disease, but the relationships between them and cerebral small vessel disease (CSVD) were unclear. Our study aimed to evaluate associations of 10-year ASCVD risk scores with CSVD and its magnetic resonance imaging (MRI) markers.
METHODS: Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. At baseline, we collected data related to the Framingham Risk Score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups. Participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score.
RESULTS: A total of 3063 participants were included, and 53.5% of them were female. A higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53-2.34; high vs. low: cOR 3.23, 95%CI 2.62-3.97), and the PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P < 0.05). Moreover, higher 10-year ASCVD scores were associated with higher odds of WMH (P < 0.05), lacunes (P < 0.05), CMBs (P < 0.05) and BG-EPVS (P < 0.05).
CONCLUSIONS: The 10-year ASCVD scores were positively associated with CSVD and its MRI markers. These scores provided a method of risk stratification in the population with CSVD.
METHODS: Community-dwelling residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study were included in this cross-sectional study. At baseline, we collected data related to the Framingham Risk Score (FRS), pooled cohort equation (PCE), prediction for ASCVD risk in China (China-PAR) and Systematic COronary Risk Evaluation model 2 (SCORE2), and classified participants into low, moderate and high groups. Participants underwent brain MRI scans. We evaluated white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS) according to criteria of Wardlaw and Rothwell, and calculated total CSVD score and modified total CSVD score.
RESULTS: A total of 3063 participants were included, and 53.5% of them were female. A higher FRS was associated with higher total CSVD score (moderate vs. low: cOR 1.89, 95% CI 1.53-2.34; high vs. low: cOR 3.23, 95%CI 2.62-3.97), and the PCE, China-PAR or SCORE2 score was positively related to total CSVD score (P < 0.05). Moreover, higher 10-year ASCVD scores were associated with higher odds of WMH (P < 0.05), lacunes (P < 0.05), CMBs (P < 0.05) and BG-EPVS (P < 0.05).
CONCLUSIONS: The 10-year ASCVD scores were positively associated with CSVD and its MRI markers. These scores provided a method of risk stratification in the population with CSVD.
摘要：
背景：10年动脉粥样硬化性心血管疾病（ASCVD）风险评分可用于预测大血管疾病，但它们与脑小血管病（CSVD）之间的关系尚不清楚。我们的研究旨在评估10年ASCVD风险评分与CSVD及其磁共振成像（MRI）标志物的相关性。
方法：这项横断面研究纳入了多血管认知损害和vaScular事件评估研究的社区居民。在基线,我们收集了与弗雷明汉风险评分(FRS)相关的数据，合并队列方程(PCE)，中国ASCVD风险预测(China-PAR)和系统冠状动脉风险评估模型2(SCORE2)，并将参与者分类为低，中高群体。参与者接受了脑部MRI扫描。我们评估了白质高强度（WMH），lacunes,根据Wardlaw和Rothwell的标准，脑微出血（CMBs）和基底神经节血管周围间隙扩大（BG-EPVS），并计算CSVD总分和修正的CSVD总分。
结果：共纳入3063名参与者，其中53.5%是女性。较高的FRS与较高的CSVD总分相关（中度与低：cOR1.89，95%CI1.53-2.34；高vs.低：COR3.23，95CI2.62-3.97），和PCE，China-PAR或SCORE2评分与CSVD总分呈正相干(P<0.05)。此外，较高的10年ASCVD评分与较高的WMH几率相关(P<0.05),空白（P<0.05），CMBs(P<0.05)和BG-EPVS(P<0.05)。
结论：10年ASCVD评分与CSVD及其MRI标志物呈正相关。这些评分提供了CSVD人群的风险分层方法。
方法：这项横断面研究纳入了多血管认知损害和vaScular事件评估研究的社区居民。在基线,我们收集了与弗雷明汉风险评分(FRS)相关的数据，合并队列方程(PCE)，中国ASCVD风险预测(China-PAR)和系统冠状动脉风险评估模型2(SCORE2)，并将参与者分类为低，中高群体。参与者接受了脑部MRI扫描。我们评估了白质高强度（WMH），lacunes,根据Wardlaw和Rothwell的标准，脑微出血（CMBs）和基底神经节血管周围间隙扩大（BG-EPVS），并计算CSVD总分和修正的CSVD总分。
结果：共纳入3063名参与者，其中53.5%是女性。较高的FRS与较高的CSVD总分相关（中度与低：cOR1.89，95%CI1.53-2.34；高vs.低：COR3.23，95CI2.62-3.97），和PCE，China-PAR或SCORE2评分与CSVD总分呈正相干(P<0.05)。此外，较高的10年ASCVD评分与较高的WMH几率相关(P<0.05),空白（P<0.05），CMBs(P<0.05)和BG-EPVS(P<0.05)。
结论：10年ASCVD评分与CSVD及其MRI标志物呈正相关。这些评分提供了CSVD人群的风险分层方法。
