Abstract：
BACKGROUND: This study investigated the association of American Heart Association\'s cardiovascular health guidelines Life\'s Essential 8 (LE8) and Life\'s Simple 7 (LS7) with carotid artery outcomes among young adults.
RESULTS: This cross-sectional study included 240 young adults (age 24.2±1.6 years) who underwent a carotid ultrasound between 2018 and 2022. LE8 score was calculated from 4 health factors (body mass index, non-high-density lipoprotein cholesterol, fasting glucose, and blood pressure), and 4 health behaviors (dietary intake, physical activity, tobacco use, and sleep). LS7 was calculated from 7 metrics (all LE8 metrics, except for sleep) with a simpler algorithm. Higher LE8 and LS7 scores both indicate better health and better adherence to American Heart Association guidelines. Carotid artery outcomes included carotid artery intima-media thickness, arterial stiffness (eg, distensibility), and echogenicity determined by grayscale median of the intima media complex. Results of linear regression analyses, adjusting for age, sex, ethnicity, and parents\' highest degree, indicated that a 1-SD increase in LE8 score was associated with 12.14 μm lower carotid artery intima-media thickness (95% CI, -20.93 to 3.35), 1.17 (10-6×m2/N) greater distensibility (95% CI, 0.09-2.24), suggesting less arterial stiffness, and 2.66 μm greater grayscale median of the intima media complex (95% CI, 0.58-4.75), suggesting less lipid deposition. Analyses using LS7 score demonstrated comparable findings. Health factor metrics demonstrated stronger association with carotid artery outcomes, as compared with behavior metrics.
CONCLUSIONS: Greater adherence to the American Heart Association\'s cardiovascular health guidelines is associated with lower risk for subclinical atherosclerosis in young adults. LE8 and LS7 demonstrated comparable associations with carotid artery outcomes.
RESULTS: This cross-sectional study included 240 young adults (age 24.2±1.6 years) who underwent a carotid ultrasound between 2018 and 2022. LE8 score was calculated from 4 health factors (body mass index, non-high-density lipoprotein cholesterol, fasting glucose, and blood pressure), and 4 health behaviors (dietary intake, physical activity, tobacco use, and sleep). LS7 was calculated from 7 metrics (all LE8 metrics, except for sleep) with a simpler algorithm. Higher LE8 and LS7 scores both indicate better health and better adherence to American Heart Association guidelines. Carotid artery outcomes included carotid artery intima-media thickness, arterial stiffness (eg, distensibility), and echogenicity determined by grayscale median of the intima media complex. Results of linear regression analyses, adjusting for age, sex, ethnicity, and parents\' highest degree, indicated that a 1-SD increase in LE8 score was associated with 12.14 μm lower carotid artery intima-media thickness (95% CI, -20.93 to 3.35), 1.17 (10-6×m2/N) greater distensibility (95% CI, 0.09-2.24), suggesting less arterial stiffness, and 2.66 μm greater grayscale median of the intima media complex (95% CI, 0.58-4.75), suggesting less lipid deposition. Analyses using LS7 score demonstrated comparable findings. Health factor metrics demonstrated stronger association with carotid artery outcomes, as compared with behavior metrics.
CONCLUSIONS: Greater adherence to the American Heart Association\'s cardiovascular health guidelines is associated with lower risk for subclinical atherosclerosis in young adults. LE8 and LS7 demonstrated comparable associations with carotid artery outcomes.
摘要：
背景：这项研究调查了美国心脏协会的心血管健康指南《生命必需8》（LE8）和《生命简单7》（LS7）与年轻人颈动脉结局的关联。
结果：这项横断面研究包括240名年轻人（年龄24.2±1.6岁），他们在2018年至2022年之间接受了颈动脉超声检查。LE8评分由4个健康因素(体重指数，非高密度脂蛋白胆固醇，空腹血糖,和血压），和4种健康行为(饮食摄入量，身体活动,烟草使用,和睡眠）。LS7是根据7个指标计算的(所有LE8指标，除了睡眠)用更简单的算法。较高的LE8和LS7评分都表明健康状况更好，并且对美国心脏协会指南的依从性更好。颈动脉结果包括颈动脉内中膜厚度,动脉僵硬度（例如，扩张性)，和回声性由内膜中膜复合体的灰度中位数确定。线性回归分析的结果，调整年龄，性别,种族,和父母的最高学位，表明LE8评分的1-SD增加与下颈动脉内膜中层厚度12.14μm相关（95％CI，-20.93至3.35），1.17（10-6×m2/N）更大的扩张性（95％CI，0.09-2.24），表明动脉僵硬度降低，内膜中膜复合体的灰度中位数高出2.66μm(95%CI，0.58-4.75)，表明脂质沉积较少。使用LS7评分的分析显示了可比较的结果。健康因素指标显示与颈动脉预后的相关性更强，与行为指标相比。
结论：对美国心脏协会心血管健康指南的更高依从性与年轻人亚临床动脉粥样硬化的风险较低相关。LE8和LS7显示出与颈动脉预后具有可比性的相关性。
结果：这项横断面研究包括240名年轻人（年龄24.2±1.6岁），他们在2018年至2022年之间接受了颈动脉超声检查。LE8评分由4个健康因素(体重指数，非高密度脂蛋白胆固醇，空腹血糖,和血压），和4种健康行为(饮食摄入量，身体活动,烟草使用,和睡眠）。LS7是根据7个指标计算的(所有LE8指标，除了睡眠)用更简单的算法。较高的LE8和LS7评分都表明健康状况更好，并且对美国心脏协会指南的依从性更好。颈动脉结果包括颈动脉内中膜厚度,动脉僵硬度（例如，扩张性)，和回声性由内膜中膜复合体的灰度中位数确定。线性回归分析的结果，调整年龄，性别,种族,和父母的最高学位，表明LE8评分的1-SD增加与下颈动脉内膜中层厚度12.14μm相关（95％CI，-20.93至3.35），1.17（10-6×m2/N）更大的扩张性（95％CI，0.09-2.24），表明动脉僵硬度降低，内膜中膜复合体的灰度中位数高出2.66μm(95%CI，0.58-4.75)，表明脂质沉积较少。使用LS7评分的分析显示了可比较的结果。健康因素指标显示与颈动脉预后的相关性更强，与行为指标相比。
结论：对美国心脏协会心血管健康指南的更高依从性与年轻人亚临床动脉粥样硬化的风险较低相关。LE8和LS7显示出与颈动脉预后具有可比性的相关性。
