PDF(Pubmed)
Abstract：
UNASSIGNED: Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD).
UNASSIGNED: The purpose of this study was to examine the association between circulating IL-6 levels and CVD events without baseline CVD across racial and ethnic groups.
UNASSIGNED: We conducted an observational analysis utilizing the MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter, prospective community-based study of CVD at baseline from four racial and ethnic groups. IL-6 levels were measured at the time of enrollment (visit 1) and were divided into 3 terciles. Patient baseline characteristics and outcomes, including all-cause mortality, CV mortality, heart failure, and non-CV mortality, were included. Cox proportional hazard regression models were used to assess associations between IL-6 levels and study outcomes with IL-6 tercile 1 as reference.
UNASSIGNED: Of 6,622 individuals, over half were women (53%) with a median age of 62 (IQR: 53-70) years. Racial and ethnic composition was non-Hispanic White (39%) followed by African American (27%), Hispanic (22%), and Chinese American (12%). Compared to tercile 1, participants with IL-6 tercile 3 had a higher adjusted risk of and all-cause mortality (HR: 1.98 [95% CI: 1.67-2.36]), CV mortality (HR: 1.55 [95% CI: 1.05-2.30]), non-CV mortality (HR: 2.05 [95% CI: 1.65-2.56]), and heart failure (HR: 1.48 [95% CI: 0.99-2.19]). When tested as a continuous variable, higher levels of IL-6 were associated with an increased risk of all individual outcomes. Compared to non-Hispanic White participants, the unadjusted and adjusted risk of all outcomes across all races and ethnicities was similar across all IL-6 terciles.
UNASSIGNED: High levels of circulating IL-6 are associated with worse CV outcomes and increased all-cause mortality consistently across all racial and ethnic groups.
UNASSIGNED: The purpose of this study was to examine the association between circulating IL-6 levels and CVD events without baseline CVD across racial and ethnic groups.
UNASSIGNED: We conducted an observational analysis utilizing the MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter, prospective community-based study of CVD at baseline from four racial and ethnic groups. IL-6 levels were measured at the time of enrollment (visit 1) and were divided into 3 terciles. Patient baseline characteristics and outcomes, including all-cause mortality, CV mortality, heart failure, and non-CV mortality, were included. Cox proportional hazard regression models were used to assess associations between IL-6 levels and study outcomes with IL-6 tercile 1 as reference.
UNASSIGNED: Of 6,622 individuals, over half were women (53%) with a median age of 62 (IQR: 53-70) years. Racial and ethnic composition was non-Hispanic White (39%) followed by African American (27%), Hispanic (22%), and Chinese American (12%). Compared to tercile 1, participants with IL-6 tercile 3 had a higher adjusted risk of and all-cause mortality (HR: 1.98 [95% CI: 1.67-2.36]), CV mortality (HR: 1.55 [95% CI: 1.05-2.30]), non-CV mortality (HR: 2.05 [95% CI: 1.65-2.56]), and heart failure (HR: 1.48 [95% CI: 0.99-2.19]). When tested as a continuous variable, higher levels of IL-6 were associated with an increased risk of all individual outcomes. Compared to non-Hispanic White participants, the unadjusted and adjusted risk of all outcomes across all races and ethnicities was similar across all IL-6 terciles.
UNASSIGNED: High levels of circulating IL-6 are associated with worse CV outcomes and increased all-cause mortality consistently across all racial and ethnic groups.
摘要：
■白细胞介素（IL）-6水平升高与有和没有基线心血管疾病（CVD）的患者的不良结局有关。
■本研究的目的是研究循环IL-6水平与无基线CVD的CVD事件之间的关系。
■我们利用MESA（多种族动脉粥样硬化研究）进行了观察性分析，一个多中心，前瞻性基于社区的基线心血管疾病研究来自四个种族和族裔群体。IL-6水平在入组时测量(第1次访问),并分成3个部分。患者基线特征和结果，包括全因死亡率,CV死亡率，心力衰竭,和非CV死亡率，包括在内。Cox比例风险回归模型用于评估IL-6水平与研究结果之间的关联，以IL-6tercile1为参考。
■在6,622个人中，超过一半的女性(53%),中位年龄为62岁(IQR:53-70).种族和种族组成是非西班牙裔白人（39％），其次是非洲裔美国人（27％）。西班牙裔（22％），美籍华人（12%）。与第1期相比，IL-6第3期的参与者具有更高的校正风险和全因死亡率(HR:1.98[95%CI:1.67-2.36])，CV死亡率（HR：1.55[95%CI：1.05-2.30]），非CV死亡率（HR：2.05[95%CI：1.65-2.56]），和心力衰竭（HR：1.48[95%CI：0.99-2.19]）。当作为连续变量测试时，IL-6水平升高与所有个体结局的风险增加相关.与非西班牙裔白人参与者相比，在所有IL-6患者中,所有种族和民族的所有结局的未校正和校正风险相似.
高水平的循环IL-6与更差的CV结果和在所有种族和族裔群体中持续增加的全因死亡率相关。
■本研究的目的是研究循环IL-6水平与无基线CVD的CVD事件之间的关系。
■我们利用MESA（多种族动脉粥样硬化研究）进行了观察性分析，一个多中心，前瞻性基于社区的基线心血管疾病研究来自四个种族和族裔群体。IL-6水平在入组时测量(第1次访问),并分成3个部分。患者基线特征和结果，包括全因死亡率,CV死亡率，心力衰竭,和非CV死亡率，包括在内。Cox比例风险回归模型用于评估IL-6水平与研究结果之间的关联，以IL-6tercile1为参考。
■在6,622个人中，超过一半的女性(53%),中位年龄为62岁(IQR:53-70).种族和种族组成是非西班牙裔白人（39％），其次是非洲裔美国人（27％）。西班牙裔（22％），美籍华人（12%）。与第1期相比，IL-6第3期的参与者具有更高的校正风险和全因死亡率(HR:1.98[95%CI:1.67-2.36])，CV死亡率（HR：1.55[95%CI：1.05-2.30]），非CV死亡率（HR：2.05[95%CI：1.65-2.56]），和心力衰竭（HR：1.48[95%CI：0.99-2.19]）。当作为连续变量测试时，IL-6水平升高与所有个体结局的风险增加相关.与非西班牙裔白人参与者相比，在所有IL-6患者中,所有种族和民族的所有结局的未校正和校正风险相似.
高水平的循环IL-6与更差的CV结果和在所有种族和族裔群体中持续增加的全因死亡率相关。
