%0 Journal Article
%T Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA.
%A Khan MS
%A Talha KM
%A Maqsood MH
%A Rymer JA
%A Borlaug BA
%A Docherty KF
%A Pandey A
%A Kahles F
%A Cikes M
%A Lam CSP
%A Ducharme A
%A Voors AA
%A Hernandez AF
%A Lincoff AM
%A Petrie MC
%A Ridker PM
%A Fudim M
%J JACC Adv
%V 3
%N 8
%D 2024 Aug
%M 39077632
暂无%R 10.1016/j.jacadv.2024.101063
%X <B>UNASSIGNED: </B>Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD).<BR><B>UNASSIGNED: </B>The purpose of this study was to examine the association between circulating IL-6 levels and CVD events without baseline CVD across racial and ethnic groups.<BR><B>UNASSIGNED: </B>We conducted an observational analysis utilizing the MESA (Multi-Ethnic Study of Atherosclerosis), a multicenter, prospective community-based study of CVD at baseline from four racial and ethnic groups. IL-6 levels were measured at the time of enrollment (visit 1) and were divided into 3 terciles. Patient baseline characteristics and outcomes, including all-cause mortality, CV mortality, heart failure, and non-CV mortality, were included. Cox proportional hazard regression models were used to assess associations between IL-6 levels and study outcomes with IL-6 tercile 1 as reference.<BR><B>UNASSIGNED: </B>Of 6,622 individuals, over half were women (53%) with a median age of 62 (IQR: 53-70) years. Racial and ethnic composition was non-Hispanic White (39%) followed by African American (27%), Hispanic (22%), and Chinese American (12%). Compared to tercile 1, participants with IL-6 tercile 3 had a higher adjusted risk of and all-cause mortality (HR: 1.98 [95% CI: 1.67-2.36]), CV mortality (HR: 1.55 [95% CI: 1.05-2.30]), non-CV mortality (HR: 2.05 [95% CI: 1.65-2.56]), and heart failure (HR: 1.48 [95% CI: 0.99-2.19]). When tested as a continuous variable, higher levels of IL-6 were associated with an increased risk of all individual outcomes. Compared to non-Hispanic White participants, the unadjusted and adjusted risk of all outcomes across all races and ethnicities was similar across all IL-6 terciles.<BR><B>UNASSIGNED: </B>High levels of circulating IL-6 are associated with worse CV outcomes and increased all-cause mortality consistently across all racial and ethnic groups.