PDF(Pubmed)
Abstract：
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, leading to various vascular complications. Accumulating evidence indicates that endothelial colony-forming cells (ECFCs) have attractive prospects for repairing and restoring blood vessels. Thus, ECFCs may be a novel therapeutic option for diabetic patients with vascular complications who require revascularization therapy. However, it has been reported that the function of ECFCs is impaired in DM, which poses challenges for the autologous transplantation of ECFCs. In this review, we summarize the molecular mechanisms that may be responsible for ECFC dysfunction and discuss potential strategies for improving the therapeutic efficacy of ECFCs derived from patients with DM. Finally, we discuss barriers to the use of ECFCs in human studies in light of the fact that there are no published reports using these cells in humans.
摘要：
糖尿病（DM）是一种以高血糖为特征的代谢性疾病，导致各种血管并发症。越来越多的证据表明，内皮集落形成细胞（ECFC）在修复和恢复血管方面具有诱人的前景。因此，对于需要血运重建治疗的糖尿病患者，ECFCs可能是一种新的治疗选择。然而,据报道，糖尿病患者的ECFC功能受损，这对ECFCs的自体移植提出了挑战。在这次审查中,我们总结了可能导致ECFC功能障碍的分子机制,并讨论了改善DM患者ECFC疗效的潜在策略.最后,我们讨论了在人体研究中使用ECFCs的障碍,因为目前还没有公开报道在人体中使用这些细胞.
