PDF(Pubmed)
Abstract：
Maintenance of autonomic homeostasis is continuously calibrated by sensory fibers of the vagus nerve and sympathetic chain that convey compound action potentials (CAPs) to the central nervous system. Lipopolysaccharide (LPS) intravenous challenge reliably elicits a robust inflammatory response that can resemble systemic inflammation and acute endotoxemia. Here, we administered LPS intravenously in nine healthy subjects while recording ventral cervical magnetoneurography (vcMNG)-derived CAPs at the rostral Right Nodose Ganglion (RNG) and the caudal Right Carotid Artery (RCA) with optically pumped magnetometers (OPM). We observed vcMNG RNG and RCA neural firing rates that tracked changes in TNF-α levels in the systemic circulation. Further, endotype subgroups based on high and low IL-6 responders segregate RNG CAP frequency (at 30-120 min) and based on high and low IL-10 response discriminate RCA CAP frequency (at 0-30 min). These vcMNG tools may enhance understanding and management of the neuroimmune axis that can guide personalized treatment based on an individual\'s distinct endophenotype.
摘要：
通过将复合动作电位（CAPs）传递到中枢神经系统的迷走神经和交感神经链的感觉纤维来连续校准自主神经稳态的维持。脂多糖（LPS）静脉内激发可靠地引发强烈的炎症反应，类似于全身性炎症和急性内毒素血症。这里,我们在9名健康受试者中静脉注射LPS,同时使用光泵磁强计(OPM)记录经腹侧右颈神经节(RNG)和尾侧右颈动脉(RCA)的颈部磁动图(vcMNG)衍生的CAPs.我们观察到vcMNGRNG和RCA神经放电率，可跟踪全身循环中TNF-α水平的变化。Further,基于高和低IL-6应答者的内生型亚组分离RNGCAP频率(在30-120分钟),并且基于高和低IL-10应答区分RCACAP频率(在0-30分钟)。这些vcMNG工具可以增强对神经免疫轴的理解和管理，可以根据个体独特的内表型指导个性化治疗。
