PDF(Pubmed)
Abstract：
Systemic inflammation generally coexists with functional limitations that seriously affect quality of life. This study aimed to investigate the association between systemic inflammation in midlife and the risk of functional limitations in late-life. A total of 10,044 participants with an average age of 53.9 ± 5.7 years at baseline were included in a cohort study. At the last follow-up, the prevalence of impaired activities of daily living (ADLs), instrumental activities of daily living (IADLs), and lower extremity function (LEF) was 14.7%, 21.6%, and 50.3%, respectively. The values of four inflammatory biomarkers were used to calculate the inflammation composite score. Compared with the participants in the lowest quartile of the inflammation composite score (Q1), those in the highest quartile (Q4) exhibited an odds ratio (OR) of 1.589 and a 95% confidence interval (CI) of 1.335-1.892 for impaired ADLs, an OR of 1.426 and a 95% CI of 1.228-1.657 for impaired IADLs, and an OR of 1.728 and a 95% CI of 1.526-1.957 for impaired LEF. The association between systemic inflammation and functional limitations was partly mediated by cardiac and brain function. The present study provides evidence that systemic inflammation in midlife is associated with a higher risk of late-life functional limitations. Protecting vital organ functions in midlife may have a positive impact on reducing the risk of future functional limitations.Trial registration: www.clinicaltrials.gov ; Unique identifier: NCT00005131.
摘要：
全身性炎症通常与严重影响生活质量的功能限制共存。本研究旨在探讨中年期全身炎症与晚期功能受限风险之间的关系。共有10044名参与者，基线时平均年龄为53.9±5.7岁，纳入队列研究。在最后一次随访中，日常生活活动受损(ADL)的患病率，日常生活工具活动(IADL)，下肢功能（LEF）为14.7%，21.6%,50.3%，分别。使用四种炎症生物标志物的值计算炎症综合评分。与炎症综合评分最低四分位数（Q1）的参与者相比，对于受损的ADL，最高四分位数（Q4）的比值比（OR）为1.589，95％置信区间（CI）为1.335-1.892，受损IADL的OR为1.426，95%CI为1.228-1.657，受损LEF的OR为1.728，95%CI为1.526-1.957。全身性炎症和功能限制之间的关联部分由心脏和脑功能介导。本研究提供的证据表明，中年时的全身性炎症与晚期功能受限的高风险相关。保护中年重要器官功能可能对降低未来功能受限的风险产生积极影响。试用注册：www。clinicaltrials.gov;唯一标识符：NCT00005131。
