Abstract：
Chemical compounds in the environment, which exhibit toxic and genotoxic activity, increase the mutational pressure on biota. This study aimed to investigate the genotoxic, mutagenic, and toxic effects of water from the Ile River and the Kapshagai Reservoir, both sites of active economic activities. Cytogenetic analysis of bone marrow from mice exposed to water samples from the Ile River and the Kapshagai Reservoir revealed a statistically significant increase in aberrant (p<0.05) and polyploid cells (p<0.01), as well as a decrease in the mitotic index (p<0.001), compared to the negative control. The water samples caused statistically significant increases in single- and double-strand DNA breaks in cells across various organs in the experimental mice compared to unexposed animals (p<0.001). These observations suggest the existence of chemical compounds within the water samples from the Kapshagai Reservoir and the Ile River, which exhibit genotoxic, mutagenic, and toxic properties.
摘要：
环境中的化学物质，表现出毒性和遗传毒性活性，增加生物群的突变压力。本研究旨在调查基因毒性，诱变，和来自Ile河和Kapshagai水库的水的毒性作用，这两个地方都是活跃的经济活动。暴露于Ile河和Kapshagai水库水样的小鼠骨髓的细胞遗传学分析显示，异常细胞（p<0.05）和多倍体细胞（p<0.01）有统计学意义的增加，以及有丝分裂指数的降低（p<0.001），与阴性对照相比。与未暴露的动物相比，水样导致实验小鼠各种器官细胞中单链和双链DNA断裂的统计学显着增加（p<0.001）。这些观察结果表明，来自Kapshagai水库和Ile河的水样中存在化学化合物，表现出基因毒性，诱变，和毒性。
