PDF(Pubmed)
Abstract：
Despite the increasing number of 3D RNA structures in the Protein Data Bank, the majority of experimental RNA structures lack thorough functional annotations. As the significance of the functional roles played by noncoding RNAs becomes increasingly apparent, comprehensive annotation of RNA function is becoming a pressing concern. In response to this need, we have developed FURNA (Functions of RNAs), the first database for experimental RNA structures that aims to provide a comprehensive repository of high-quality functional annotations. These include Gene Ontology terms, Enzyme Commission numbers, ligand-binding sites, RNA families, protein-binding motifs, and cross-references to related databases. FURNA is available at https://seq2fun.dcmb.med.umich.edu/furna/ to enable quick discovery of RNA functions from their structures and sequences.
摘要：
尽管蛋白质数据库中的3DRNA结构数量不断增加，大多数实验RNA结构缺乏彻底的功能注释。随着非编码RNA的功能作用的重要性变得越来越明显，RNA功能的全面注释正成为一个紧迫的问题。为了满足这一需要,我们开发了FURNA（RNA的功能），第一个用于实验RNA结构的数据库，旨在提供高质量功能注释的全面存储库。这些包括基因本体术语，酶委员会编号，配体结合位点，RNA家族,蛋白质结合基序，以及相关数据库的交叉引用。FURNA可在https://seq2fun获得。dcmb.med.umich.edu/furna/能够从其结构和序列中快速发现RNA功能。
