Abstract：
OBJECTIVE: Fetuin-B is a hepatokine/adipokine implicated in glucose homeostasis and lipid metabolism. We sought to assess whether cord blood fetuin-B levels are altered in gestational diabetes mellitus (GDM) and the association with fetal growth factors and lipids.
UNASSIGNED: In a nested case-control study of 153 pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we assessed cord blood fetuin-B in relation to fetal growth factors and lipids [high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterols (TC) and triglycerides (TG)].
RESULTS: Cord blood fetuin-B concentrations were higher in the newborns of GDM vs. euglycemic mothers (mean ± SD: 2.35±0.96 vs 2.05±0.73 mg/L, P=0.012), and were positively correlated with LDL (r=0.239, P<0.0001), TC (r=0.230, P=0.0001), insulin-like growth factor-Ⅰ [IGF-Ⅰ (r=0.137, P=0.023)] and IGF-Ⅱ (r=0.148, P=0.014) concentrations. Similar associations were observed adjusting for maternal and neonatal characteristics.
CONCLUSIONS: The study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of insulin-like growth factors (IGF-Ⅰ and IGF-Ⅱ).
UNASSIGNED: In a nested case-control study of 153 pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we assessed cord blood fetuin-B in relation to fetal growth factors and lipids [high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterols (TC) and triglycerides (TG)].
RESULTS: Cord blood fetuin-B concentrations were higher in the newborns of GDM vs. euglycemic mothers (mean ± SD: 2.35±0.96 vs 2.05±0.73 mg/L, P=0.012), and were positively correlated with LDL (r=0.239, P<0.0001), TC (r=0.230, P=0.0001), insulin-like growth factor-Ⅰ [IGF-Ⅰ (r=0.137, P=0.023)] and IGF-Ⅱ (r=0.148, P=0.014) concentrations. Similar associations were observed adjusting for maternal and neonatal characteristics.
CONCLUSIONS: The study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of insulin-like growth factors (IGF-Ⅰ and IGF-Ⅱ).
摘要：
目的：胎球蛋白B是一种与葡萄糖稳态和脂质代谢有关的肝细胞/脂肪因子。我们试图评估妊娠期糖尿病（GDM）中脐带血胎球蛋白B水平是否发生变化，以及与胎儿生长因子和脂质的关系。
■在一项对上海出生队列中153对GDM和正常血糖妊娠的母亲的巢式病例对照研究中，我们评估了脐带血胎球蛋白B与胎儿生长因子和脂质的关系[高密度脂蛋白（HDL），低密度脂蛋白（LDL），总胆固醇（TC）和甘油三酯（TG）]。
结果：GDM新生儿脐血胎球蛋白B浓度高于正常血糖的母亲（平均值±SD：2.35±0.96vs2.05±0.73mg/L，P=0.012),与LDL呈正相关(r=0.239,P<0.0001),TC(r=0.230,P=0.0001),胰岛素样生长因子-Ⅰ[IGF-Ⅰ(r=0.137,P=0.023)]和IGF-Ⅱ(r=0.148,P=0.014)浓度。根据母体和新生儿特征进行调整，观察到类似的关联。
结论：这项研究首次证明胎球蛋白B水平在GDM的胎儿期升高，并且胎球蛋白B会影响人类胎儿时期的脂质代谢健康。胎球蛋白B的分泌与胰岛素样生长因子(IGF-Ⅰ和IGF-Ⅱ)的分泌有关。
■在一项对上海出生队列中153对GDM和正常血糖妊娠的母亲的巢式病例对照研究中，我们评估了脐带血胎球蛋白B与胎儿生长因子和脂质的关系[高密度脂蛋白（HDL），低密度脂蛋白（LDL），总胆固醇（TC）和甘油三酯（TG）]。
结果：GDM新生儿脐血胎球蛋白B浓度高于正常血糖的母亲（平均值±SD：2.35±0.96vs2.05±0.73mg/L，P=0.012),与LDL呈正相关(r=0.239,P<0.0001),TC(r=0.230,P=0.0001),胰岛素样生长因子-Ⅰ[IGF-Ⅰ(r=0.137,P=0.023)]和IGF-Ⅱ(r=0.148,P=0.014)浓度。根据母体和新生儿特征进行调整，观察到类似的关联。
结论：这项研究首次证明胎球蛋白B水平在GDM的胎儿期升高，并且胎球蛋白B会影响人类胎儿时期的脂质代谢健康。胎球蛋白B的分泌与胰岛素样生长因子(IGF-Ⅰ和IGF-Ⅱ)的分泌有关。
