UNASSIGNED: In a nested case-control study of 153 pairs of neonates of mothers with GDM and euglycemic pregnancies in the Shanghai Birth Cohort, we assessed cord blood fetuin-B in relation to fetal growth factors and lipids [high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterols (TC) and triglycerides (TG)].
RESULTS: Cord blood fetuin-B concentrations were higher in the newborns of GDM vs. euglycemic mothers (mean ± SD: 2.35±0.96 vs 2.05±0.73 mg/L, P=0.012), and were positively correlated with LDL (r=0.239, P<0.0001), TC (r=0.230, P=0.0001), insulin-like growth factor-Ⅰ [IGF-Ⅰ (r=0.137, P=0.023)] and IGF-Ⅱ (r=0.148, P=0.014) concentrations. Similar associations were observed adjusting for maternal and neonatal characteristics.
CONCLUSIONS: The study is the first to demonstrate that fetuin-B levels are elevated in fetal life in GDM, and that fetuin-B affects lipid metabolic health during fetal life in humans. The secretion of fetuin-B appears to be related to the secretion of insulin-like growth factors (IGF-Ⅰ and IGF-Ⅱ).
■在一项对上海出生队列中153对GDM和正常血糖妊娠的母亲的巢式病例对照研究中,我们评估了脐带血胎球蛋白B与胎儿生长因子和脂质的关系[高密度脂蛋白(HDL),低密度脂蛋白(LDL),总胆固醇(TC)和甘油三酯(TG)]。
结果:GDM新生儿脐血胎球蛋白B浓度高于正常血糖的母亲(平均值±SD:2.35±0.96vs2.05±0.73mg/L,P=0.012),与LDL呈正相关(r=0.239,P<0.0001),TC(r=0.230,P=0.0001),胰岛素样生长因子-Ⅰ[IGF-Ⅰ(r=0.137,P=0.023)]和IGF-Ⅱ(r=0.148,P=0.014)浓度。根据母体和新生儿特征进行调整,观察到类似的关联。
结论:这项研究首次证明胎球蛋白B水平在GDM的胎儿期升高,并且胎球蛋白B会影响人类胎儿时期的脂质代谢健康。胎球蛋白B的分泌与胰岛素样生长因子(IGF-Ⅰ和IGF-Ⅱ)的分泌有关。