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Abstract：
Nanomechanical sensors, due to their small size and high sensitivity to the environment, hold significant promise for various sensing applications. These sensors enable rapid, highly sensitive, and selective detection of biological and biochemical entities as well as mass spectrometry by utilizing the frequency shift of nanomechanical resonators. Nanomechanical systems have been employed to measure the mass of cells and biomolecules and study the fundamentals of surface science such as phase transitions and diffusion. Here, we develop a methodology using both experimental measurements and numerical simulations to explore the characteristics of nanomechanical resonators when the detection entities are absorbed on the cantilever surface and quantify the mass, density, and Young\'s modulus of adsorbed entities. Moreover, based on this proposed concept, we present an experimental method for measuring the mass of molecules and living biological entities in their physiological environment. This approach could find applications in predicting the behavior of bionanoelectromechanical resonators functionalized with biological capture molecules, as well as in label-free, nonfunctionalized micro/nanoscale biosensing and mass spectrometry of living bioentities.
摘要：
纳米机械传感器,由于它们的体积小和对环境的高灵敏度，对各种传感应用具有重要的前景。这些传感器能够快速，高度敏感,通过利用纳米机械谐振器的频移来选择性检测生物和生物化学实体以及质谱。纳米机械系统已用于测量细胞和生物分子的质量，并研究表面科学的基础，例如相变和扩散。这里,我们开发了一种方法，使用实验测量和数值模拟来探索纳米机械谐振器的特性，当检测实体被吸收在悬臂表面并量化质量时，密度,和吸附实体的杨氏模量。此外，基于这个提出的概念，我们提出了一种实验方法，用于测量分子和生物实体在其生理环境中的质量。这种方法可以在预测用生物捕获分子功能化的生物纳米机电谐振器的行为中找到应用。以及无标签，非功能化的微/纳米级生物传感和活生物实体的质谱。
