PDF(Pubmed)
Abstract：
Premenstrual syndrome (PMS) has various symptoms that occur during the luteal phase of the menstrual cycle and subside after menstruation. Anxiety and depression are prevalent in women with PMS and may exacerbate the severity of PMS. Vitamin D and calcium deficiency may have a role in developing anxiety, depression, and musculoskeletal pain (MSP). The aim of this study was to evaluate selected premenstrual symptoms in relation to serum vitamin D levels, daily calcium consumption, and psychological symptoms among women with MSP. The study population consisted of 108 women with MSP and 108 healthy controls. Information about premenstrual symptoms and calcium consumption were collected. Psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Vitamin D was determined by electrochemiluminescence immunoassay. Women with MSP had lower serum vitamin D levels, lower daily calcium consumption, higher HADS scores for anxiety and depression, and higher frequency of severe premenstrual symptoms including fatigue, headache, irritability, mood swings, anxiety, depression, and social withdrawal compared to controls (P < 0.01). Abnormal HADS scores for anxiety and depression were associated with increased severity of premenstrual symptoms (P < 0.05). Deficient vitamin D and calcium consumption were associated with abnormal HADS scores for anxiety and depression (P < 0.05) and with increased severity of premenstrual headache, irritability, anxiety, and depression (P < 0.05). Low calcium consumption was associated with increased severity of premenstrual irritability, anxiety, depression, and social withdrawal (P < 0.05). The results suggest that vitamin D deficiency, low calcium consumption, psychological symptoms, and MSP could be interrelated and implicated in the etiology severe premenstrual symptoms. Further studies are necessary to assess whether vitamin D and calcium supplements can relieve MSP and premenstrual symptoms.
摘要：
经前期综合征（PMS）具有在月经周期的黄体期发生的各种症状，并在月经后消退。焦虑和抑郁在患有PMS的女性中普遍存在，并可能加剧PMS的严重程度。维生素D和钙缺乏可能在发展焦虑中起作用，抑郁症,肌肉骨骼疼痛（MSP）。这项研究的目的是评估与血清维生素D水平相关的经前期症状。每日钙消耗，和MSP女性的心理症状。研究人群包括108名MSP女性和108名健康对照。收集有关经前症状和钙消耗的信息。使用医院焦虑和抑郁量表（HADS）评估心理症状。通过电化学发光免疫分析法测定维生素D。MSP患者血清维生素D水平较低，降低每日钙消耗，焦虑和抑郁的HADS评分更高，包括疲劳在内的严重经前症状的频率更高，头痛,烦躁，情绪波动,焦虑,抑郁症,与对照组相比，社会退缩（P<0.01）。焦虑和抑郁的HADS评分异常与经前期症状严重程度增加相关(P<0.05)。维生素D和钙消耗不足与焦虑和抑郁的HADS评分异常相关（P<0.05），经前头痛的严重程度增加。烦躁，焦虑,抑郁(P<0.05)。低钙消耗与经前烦躁不安的严重程度增加有关，焦虑,抑郁症,社会退缩(P<0.05)。结果表明，维生素D缺乏，低钙消耗，心理症状,和MSP可能相互关联，并与严重的经前症状有关。需要进一步的研究来评估维生素D和钙补充剂是否可以缓解MSP和经前症状。
