结论:EGFR将生长因子的信号传导到细胞增殖中,并且在肿瘤中经常被过度激活。N361的EGFR糖基化调节EGFR二聚化,增殖信号的生长因子刺激,和对靶向抑制的敏感性。对EGFR糖基化的见解可能会扩大治疗机会,使癌症患者受益。
N361 糖基化对表皮生长因子受体生物学功能的影响.
关键词: 293T AREG CellTiter-Glo EGF EGFR ERK Glycosylation L858R MCF10A N337 N361 N361A PLA amphiregulin binding breast cancer cancer cell biology co-localization dimerization epidermal growth factor epidermal growth factor receptor flow cytometry immunoblot inhibitor ligand localization lung cancer necitumumab non-small cell lung cancer osimertinib phosphorylation proliferation proximity ligation assay signaling
来 源:
DOI:10.1101/2024.07.12.603279
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