PDF(Pubmed)
Abstract：
BACKGROUND: Hepatoid adenocarcinoma of the lung (HAL) is a rare type of non-small cell lung cancer (NSCLC), histologically similar to hepatocellular carcinoma. HAL has high malignancy and poor prognosis, and a better treatment plan needs further study.
METHODS: In order to deeply understand the occurrence and development of HAL, here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T mutation. The patient refused chemotherapy and received one course of treatment (immune checkpoint inhibitors), and died three months later due to progressive disease.
CONCLUSIONS: HAL is a special type of NSCLC. The surgical treatment of HAL in the limited stage can achieve long-term survival, but most of them were in the advanced stage when they were found, and the prognosis was poor, which requires multidisciplinary comprehensive treatment.
METHODS: In order to deeply understand the occurrence and development of HAL, here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T mutation. The patient refused chemotherapy and received one course of treatment (immune checkpoint inhibitors), and died three months later due to progressive disease.
CONCLUSIONS: HAL is a special type of NSCLC. The surgical treatment of HAL in the limited stage can achieve long-term survival, but most of them were in the advanced stage when they were found, and the prognosis was poor, which requires multidisciplinary comprehensive treatment.
摘要：
背景：肺肝样腺癌（HAL）是一种罕见的非小细胞肺癌（NSCLC），组织学上与肝细胞癌相似。HAL恶性程度高,预后差,更好的治疗方案需要进一步研究。
方法：为了深入了解HAL的发生和发展，我们报告一例甲胎蛋白阴性KRASA146T突变广泛转移的HAL。患者拒绝化疗，接受一个疗程的治疗（免疫检查点抑制剂），三个月后因疾病进展而死亡。
结论：HAL是一种特殊类型的非小细胞肺癌。在有限的阶段手术治疗HAL可以实现长期生存，但是当他们被发现时，他们中的大多数都处于晚期，预后很差，这需要多学科综合治疗。
方法：为了深入了解HAL的发生和发展，我们报告一例甲胎蛋白阴性KRASA146T突变广泛转移的HAL。患者拒绝化疗，接受一个疗程的治疗（免疫检查点抑制剂），三个月后因疾病进展而死亡。
结论：HAL是一种特殊类型的非小细胞肺癌。在有限的阶段手术治疗HAL可以实现长期生存，但是当他们被发现时，他们中的大多数都处于晚期，预后很差，这需要多学科综合治疗。
