%0 Case Reports
%T Hepatoid adenocarcinoma of the lung: A case report.
%A Mo YJ
%A Lin LN
%A Tao JL
%A Zhang T
%A Zhang JH
%J World J Clin Cases
%V 12
%N 21
%D 2024 Jul 26
%M 39070823
%F 1.534
%R 10.12998/wjcc.v12.i21.4813
%X <B>BACKGROUND: </B>Hepatoid adenocarcinoma of the lung (HAL) is a rare type of non-small cell lung cancer (NSCLC), histologically similar to hepatocellular carcinoma. HAL has high malignancy and poor prognosis, and a better treatment plan needs further study.<BR><B>METHODS: </B>In order to deeply understand the occurrence and development of HAL, here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T mutation. The patient refused chemotherapy and received one course of treatment (immune checkpoint inhibitors), and died three months later due to progressive disease.<BR><B>CONCLUSIONS: </B>HAL is a special type of NSCLC. The surgical treatment of HAL in the limited stage can achieve long-term survival, but most of them were in the advanced stage when they were found, and the prognosis was poor, which requires multidisciplinary comprehensive treatment.