PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory subtype of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD, a common, multifactorial and poorly understood liver disease whose incidence is increasing worldwide. In recent years, there has been increasing scientific interest in exploring the relationship between gut microbiota and MASH. To learn more about the gut microbiota in MASH, this study aims to provide a comprehensive analysis of the knowledge structure and research hotspots from a bibliometric perspective.
UNASSIGNED: We searched the Web of Science Core Collection for articles and reviews that covered the connections between gut microbiota and MASH over the last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, the R tool \"bibliometrix\" were used to analyzed existing publications trends and hotspots.
UNASSIGNED: A total of 4,069 documents related to the interaction between gut microbiota and MASH were retrieved from 2014 to 2023. The number of annual publications increased significantly over the last decade, particularly in the United States and China. The University of California-San Diego was the most productive institution, while researcher Rohit Loomba published the most papers in the field. Younossi ZM was ranked as the first co-cited author and largest contributor of highly cited articles in the field. Gastroenterology and hepatology were the most common specialty category. The most cited journal in the last decade was Hepatology. The Keyword Bursts analysis highlighted the importance of studying the association between gut microbiota and MASH, as well as related factors such as metabolic syndrome, insulin resistance, endotoxemia and overgrowth of gut bacteria. Keyword clusters with co-citation were used to illustrate important topics including intestinal permeability, insulin sensitivity and liver immunology. The most common keywords include insulin resistance, obesity, dysbiosis, inflammation and oxidative stress, which are current hotspots.
UNASSIGNED: Our analysis highlights key aspects of this field and emphasizes multiorgan crosstalk in MASLD/MASH pathogenesis. In particular, the central role of the gut-liver axis and the significant influence of gut microbiota dysbiosis on disease progression are highlighted. Furthermore, our results highlight the transformative potential of microbiota-specific therapies and cover the way for innovative healthcare and pharmaceutical strategies.
UNASSIGNED: We searched the Web of Science Core Collection for articles and reviews that covered the connections between gut microbiota and MASH over the last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, the R tool \"bibliometrix\" were used to analyzed existing publications trends and hotspots.
UNASSIGNED: A total of 4,069 documents related to the interaction between gut microbiota and MASH were retrieved from 2014 to 2023. The number of annual publications increased significantly over the last decade, particularly in the United States and China. The University of California-San Diego was the most productive institution, while researcher Rohit Loomba published the most papers in the field. Younossi ZM was ranked as the first co-cited author and largest contributor of highly cited articles in the field. Gastroenterology and hepatology were the most common specialty category. The most cited journal in the last decade was Hepatology. The Keyword Bursts analysis highlighted the importance of studying the association between gut microbiota and MASH, as well as related factors such as metabolic syndrome, insulin resistance, endotoxemia and overgrowth of gut bacteria. Keyword clusters with co-citation were used to illustrate important topics including intestinal permeability, insulin sensitivity and liver immunology. The most common keywords include insulin resistance, obesity, dysbiosis, inflammation and oxidative stress, which are current hotspots.
UNASSIGNED: Our analysis highlights key aspects of this field and emphasizes multiorgan crosstalk in MASLD/MASH pathogenesis. In particular, the central role of the gut-liver axis and the significant influence of gut microbiota dysbiosis on disease progression are highlighted. Furthermore, our results highlight the transformative potential of microbiota-specific therapies and cover the way for innovative healthcare and pharmaceutical strategies.
摘要：
■代谢功能障碍相关脂肪性肝炎（MASH）是代谢功能障碍相关脂肪性肝病（MASLD）的一种炎性亚型，最近被提议作为NAFLD的替代术语。一个普通的,多因素和鲜为人知的肝病，其发病率在全球范围内不断增加。近年来,人们对探索肠道微生物群与MASH之间的关系越来越感兴趣。要了解有关MASH中肠道微生物群的更多信息，本研究旨在从文献计量的角度对知识结构和研究热点进行全面分析。
■我们搜索了WebofScienceCoreCollection的文章和评论，这些文章和评论涵盖了过去十年中肠道微生物群与MASH之间的联系。在线分析平台，VOSviewer,CiteSpace,R工具“bibliometrix”用于分析现有出版物的趋势和热点。
■从2014年至2023年，共检索了4,069篇与肠道微生物群与MASH之间相互作用有关的文献。过去十年来，年度出版物数量大幅增加，特别是在美国和中国。加州大学圣地亚哥分校是生产力最高的机构，而研究员RohitLoomba发表了该领域最多的论文。YounossiZM被评为该领域高被引用文章的第一位共同引用作者和最大贡献者。胃肠病学和肝病学是最常见的专业类别。过去十年中被引用最多的期刊是肝病学。关键字爆发分析强调了研究肠道微生物群与MASH之间关联的重要性，以及代谢综合征等相关因素，胰岛素抵抗，内毒素血症和肠道细菌过度生长。关键词集群与共同引用被用来说明重要的主题，包括肠道通透性，胰岛素敏感性和肝脏免疫学。最常见的关键词包括胰岛素抵抗，肥胖，生态失调,炎症和氧化应激，这是当前的热点。
■我们的分析突出了该领域的关键方面，并强调了MASLD/MASH发病机理中的多器官串扰。特别是,强调了肠-肝轴的中心作用以及肠道微生物群失调对疾病进展的重要影响。此外，我们的研究结果突出了微生物群特异性疗法的转化潜力,并涵盖了创新医疗保健和制药策略的途径.
■我们搜索了WebofScienceCoreCollection的文章和评论，这些文章和评论涵盖了过去十年中肠道微生物群与MASH之间的联系。在线分析平台，VOSviewer,CiteSpace,R工具“bibliometrix”用于分析现有出版物的趋势和热点。
■从2014年至2023年，共检索了4,069篇与肠道微生物群与MASH之间相互作用有关的文献。过去十年来，年度出版物数量大幅增加，特别是在美国和中国。加州大学圣地亚哥分校是生产力最高的机构，而研究员RohitLoomba发表了该领域最多的论文。YounossiZM被评为该领域高被引用文章的第一位共同引用作者和最大贡献者。胃肠病学和肝病学是最常见的专业类别。过去十年中被引用最多的期刊是肝病学。关键字爆发分析强调了研究肠道微生物群与MASH之间关联的重要性，以及代谢综合征等相关因素，胰岛素抵抗，内毒素血症和肠道细菌过度生长。关键词集群与共同引用被用来说明重要的主题，包括肠道通透性，胰岛素敏感性和肝脏免疫学。最常见的关键词包括胰岛素抵抗，肥胖，生态失调,炎症和氧化应激，这是当前的热点。
■我们的分析突出了该领域的关键方面，并强调了MASLD/MASH发病机理中的多器官串扰。特别是,强调了肠-肝轴的中心作用以及肠道微生物群失调对疾病进展的重要影响。此外，我们的研究结果突出了微生物群特异性疗法的转化潜力,并涵盖了创新医疗保健和制药策略的途径.
