PDF(Pubmed)
Abstract：
UNASSIGNED: Delayed cord clamping (DCC) occurs in most preterm births.
UNASSIGNED: Evaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes.
UNASSIGNED: Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 240/7 to 276/7 weeks\' gestation. AKI and two year kidney outcomes were compared in neonates with DCC (≥30 seconds after delivery) to those with early cord clamping (ECC) (<30 seconds after delivery).
UNASSIGNED: The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold times increased adjusted odds of eGFR <90 mL/min/1.73m2. No significant associations were noted between DCC and albuminuria or elevated BP.
UNASSIGNED: DCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m2 at two years.
UNASSIGNED: Evaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes.
UNASSIGNED: Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 240/7 to 276/7 weeks\' gestation. AKI and two year kidney outcomes were compared in neonates with DCC (≥30 seconds after delivery) to those with early cord clamping (ECC) (<30 seconds after delivery).
UNASSIGNED: The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold times increased adjusted odds of eGFR <90 mL/min/1.73m2. No significant associations were noted between DCC and albuminuria or elevated BP.
UNASSIGNED: DCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m2 at two years.
摘要：
背景：脐带夹闭延迟（DCC）发生在大多数早产中。目的：评估DCC与急性肾损伤（AKI）和2年肾脏预后的关系。方法：对妊娠240/7至276/7周新生儿的早产促红细胞生成素神经保护试验进行二次分析。比较了患有DCC（分娩后≥30秒）的新生儿与患有早期脐带钳夹（ECC）（分娩后<30秒）的新生儿的AKI和两年肾脏结局。结果：AKI的发生率和严重程度在DCC组和ECC组之间没有差异（aOR1.17[95CI0.76-1.80]）。在矫正两岁的时候，DCC与eGFR<90mL/min/1.73m2的校正几率增加4.5倍相关。DCC与白蛋白尿或血压升高之间没有显著关联。结论:DCC与新生儿AKI降低无关,但与2年时eGFR<90mL/min/1.73m2的校正几率较高相关。
