{Reference Type}: Journal Article
{Title}: Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).
{Author}: Harer M;Zapata H;Todurkar N;Favel K;Griffin R;Starr M;Charlton J;McAdams R;Askenazi D;Kulkarni T;Menon S;Mammen C;
{Journal}: Res Sq
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 19
暂无{DOI}: 10.21203/rs.3.rs-4631779/v1
{Abstract}: <B>UNASSIGNED: </B>Delayed cord clamping (DCC) occurs in most preterm births.<BR><B>UNASSIGNED: </B>Evaluate the association of DCC with acute kidney injury (AKI) and two-year kidney outcomes.<BR><B>UNASSIGNED: </B>Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial of neonates born 240/7 to 276/7 weeks' gestation. AKI and two year kidney outcomes were compared in neonates with DCC (≥30 seconds after delivery) to those with early cord clamping (ECC) (<30 seconds after delivery).<BR><B>UNASSIGNED: </B>The incidence and severity of AKI did not differ between the DCC and ECC groups (aOR 1.17 [95%CI 0.76-1.80]). At two years corrected age, DCC was associated with a 4.5-fold times increased adjusted odds of eGFR <90 mL/min/1.73m2. No significant associations were noted between DCC and albuminuria or elevated BP.<BR><B>UNASSIGNED: </B>DCC was not associated with decreased neonatal AKI, but was associated with higher adjusted odds of eGFR <90 mL/min/1.73m2 at two years.