PDF(Pubmed)
Abstract：
Selective serotonin reuptake inhibitors (SSRIs) are typically prescribed for treating major depressive disorder (MDD) due to their high efficacy. These drugs function by inhibiting the reuptake of serotonin [also termed 5-hydroxytryptamine (5-HT)], which raises the levels of 5-HT in the synaptic cleft, leading to prolonged activation of postsynaptic 5-HT receptors. Despite the therapeutic benefits of SSRIs, this mechanism of action also disturbs the neuroendocrine response. Hypothalamic-pituitary-adrenal (HPA) axis activity is strongly linked to both MDD and the response to antidepressants, owing to the intricate interplay within the serotonergic system, which regulates feeding, water intake, sexual drive, reproduction and circadian rhythms. The aim of the present review was to provide up-to-date evidence for the proposed effects of SSRIs, such as fluoxetine, citalopram, escitalopram, paroxetine, sertraline and fluvoxamine, on the endocrine system. For this purpose, the literature related to the effects of SSRIs on the endocrine system was searched using the PubMed database. According to the available literature, SSRIs may have an adverse effect on glucose metabolism, sexual function and fertility by dysregulating the function of the HPA axis, pancreas and gonads. Therefore, considering that SSRIs are often prescribed for extended periods, it is crucial to monitor the patient closely with particular attention to the function of the endocrine system.
摘要：
选择性5-羟色胺再摄取抑制剂(SSRIs)通常被规定用于治疗重度抑郁症(MDD),因为它们的高功效。这些药物通过抑制5-羟色胺（也称为5-羟色胺（5-HT））的再摄取起作用，这提高了突触间隙中5-HT的水平，导致突触后5-HT受体的长期激活。尽管SSRIs的治疗益处，这种作用机制也扰乱了神经内分泌反应。下丘脑-垂体-肾上腺（HPA）轴活动与MDD和对抗抑郁药的反应密切相关，由于血清素能系统内复杂的相互作用，它调节喂养，取水,性欲,繁殖和昼夜节律。本审查的目的是为SSRIs的拟议效果提供最新证据，比如氟西汀,西酞普兰,艾司西酞普兰,帕罗西汀,舍曲林和氟伏沙明，内分泌系统。为此,使用PubMed数据库检索SSRIs对内分泌系统影响的相关文献.根据现有文献,SSRIs可能对葡萄糖代谢产生不利影响，通过失调HPA轴的功能，性功能和生育能力，胰腺和性腺.因此,考虑到SSRIs通常是长期规定的，密切监测病人，特别注意内分泌系统的功能是至关重要的。
