Abstract：
Our understanding of the roles that mitochondria play in cellular physiology has evolved drastically-from a mere cellular energy supplier to a crucial regulator of metabolic and signaling processes, particularly in the context of development and progression of human diseases such as cancers. The present review examines the role of OMA1, a conserved, redox-sensitive metallopeptidase in cancer biology. OMA1\'s involvement in mitochondrial quality control, redox activity, and stress responses underscores its potential as a novel target in cancer diagnosis and treatment. However, our incomplete understanding of OMA1\'s regulation and structural detail presents ongoing challenges to target OMA1 for therapeutic purposes. Further exploration of OMA1 holds promise in uncovering novel insights into cancer mechanisms and therapeutic strategies. In this chapter, we briefly summarize our current knowledge about OMA1, its redox-regulation, and emerging role in certain cancers.
摘要：
我们对线粒体在细胞生理学中扮演的角色的理解已经从单纯的细胞能量供应者发展成为代谢和信号传导过程的关键调节剂，特别是在人类疾病如癌症的发展和进展的背景下。本综述探讨了OMA1的作用，OMA1是一种保守的，氧化还原敏感性金属肽酶在癌症生物学中的作用.OMA1参与线粒体质量控制，氧化还原活性，应激反应强调了其作为癌症诊断和治疗新靶点的潜力。然而,我们对OMA1的调控和结构细节的不完全理解对靶向OMA1进行治疗提出了持续的挑战.OMA1的进一步探索有望发现癌症机制和治疗策略的新见解。在这一章中,我们简要总结了我们目前关于OMA1，其氧化还原调节，以及在某些癌症中的新兴作用。
