PDF(Pubmed)
Abstract：
OBJECTIVE: Vitamin D deficiency and variations in the vitamin D binding protein (VDBP) gene may play a role in the development of Polycystic ovary syndrome (PCOS). This study aims to investigate the association of the rs4588 polymorphism with PCOS in Iranian women, as well as its association with infertility and recurrent pregnancy loss (RPL) in these patients.
RESULTS: The analysis revealed statistically significant differences in the distributions of genotypes and alleles of the rs4588 polymorphism among the three groups (p < 0.0001). The AC genotype and A allele showed an association with an elevated risk of PCOS and infertility. In this study, no association was found between genotypes and alleles of the rs4588 polymorphism and the risk of RPL in women with PCOS. Subjects with the AA or AC genotype exhibited significantly higher levels of LDL compared to those with the CC genotype.
RESULTS: The analysis revealed statistically significant differences in the distributions of genotypes and alleles of the rs4588 polymorphism among the three groups (p < 0.0001). The AC genotype and A allele showed an association with an elevated risk of PCOS and infertility. In this study, no association was found between genotypes and alleles of the rs4588 polymorphism and the risk of RPL in women with PCOS. Subjects with the AA or AC genotype exhibited significantly higher levels of LDL compared to those with the CC genotype.
摘要：
目的：维生素D缺乏和维生素D结合蛋白（VDBP）基因变异可能在多囊卵巢综合征（PCOS）的发生发展中起作用。本研究旨在调查rs4588多态性与伊朗女性PCOS的相关性。以及与这些患者的不孕症和复发性妊娠丢失（RPL）的关系。
结果：分析显示，rs4588多态性的基因型和等位基因分布在三组之间具有统计学上的显着差异（p<0.0001）。AC基因型和A等位基因与PCOS和不孕症的风险升高有关。在这项研究中,在PCOS女性患者中,rs4588多态性的基因型和等位基因与RPL风险之间未发现关联.与具有CC基因型的受试者相比,具有AA或AC基因型的受试者表现出显著更高水平的LDL。
结果：分析显示，rs4588多态性的基因型和等位基因分布在三组之间具有统计学上的显着差异（p<0.0001）。AC基因型和A等位基因与PCOS和不孕症的风险升高有关。在这项研究中,在PCOS女性患者中,rs4588多态性的基因型和等位基因与RPL风险之间未发现关联.与具有CC基因型的受试者相比,具有AA或AC基因型的受试者表现出显著更高水平的LDL。
