PDF(Pubmed)
Abstract：
OBJECTIVE: Cerebrovascular events during thrombolysis in cardiac arrest (CA) caused by pulmonary embolism (PE) is a life-threatening condition. However, the balance between cerebrovascular events and thrombolytic therapy in PE-induced CA remains a great challenge.
METHODS: In this study, we reported three unique cases regarding main concerns surrounding cerebrovascular events in thrombolytic therapy in PE-induced CA.
RESULTS: The patient in the case 1 treated with thrombolysis during CPR and finally discharged neurologically intact. The patient in the case 2 received delayed thrombolysis and died eventually. The patient in the case 3 was contraindicated to thrombolysis due to the complication of subarachioid hemorrahage and died within days.
CONCLUSIONS: Our case series highlights three proposed approaches to consider before administering thrombolysis as a treatment option in PE-induced CA patients: (1) prolonging the resuscitation, (2) administering thrombolysis promptly, and (3) ruling out cerebrovascular events.
METHODS: In this study, we reported three unique cases regarding main concerns surrounding cerebrovascular events in thrombolytic therapy in PE-induced CA.
RESULTS: The patient in the case 1 treated with thrombolysis during CPR and finally discharged neurologically intact. The patient in the case 2 received delayed thrombolysis and died eventually. The patient in the case 3 was contraindicated to thrombolysis due to the complication of subarachioid hemorrahage and died within days.
CONCLUSIONS: Our case series highlights three proposed approaches to consider before administering thrombolysis as a treatment option in PE-induced CA patients: (1) prolonging the resuscitation, (2) administering thrombolysis promptly, and (3) ruling out cerebrovascular events.
摘要：
目的：由肺栓塞（PE）引起的心脏骤停（CA）溶栓过程中的脑血管事件是一种危及生命的疾病。然而,在PE诱导的CA中,脑血管事件和溶栓治疗之间的平衡仍然是一个巨大的挑战.
方法：在本研究中，我们报道了3例独特病例,涉及PE诱导的CA溶栓治疗中脑血管事件的主要关注点.
结果：病例1中的患者在CPR期间接受溶栓治疗，并最终在神经功能上完好无损地出院。病例2患者接受延迟溶栓治疗，最终死亡。病例3中的患者由于动脉下血肿的并发症而禁忌溶栓，并在几天内死亡。
结论：我们的病例系列重点介绍了在PE诱发的CA患者进行溶栓治疗前考虑的三种建议方法：（1）延长复苏时间，（2）及时给予溶栓，(3)排除脑血管事件。
方法：在本研究中，我们报道了3例独特病例,涉及PE诱导的CA溶栓治疗中脑血管事件的主要关注点.
结果：病例1中的患者在CPR期间接受溶栓治疗，并最终在神经功能上完好无损地出院。病例2患者接受延迟溶栓治疗，最终死亡。病例3中的患者由于动脉下血肿的并发症而禁忌溶栓，并在几天内死亡。
结论：我们的病例系列重点介绍了在PE诱发的CA患者进行溶栓治疗前考虑的三种建议方法：（1）延长复苏时间，（2）及时给予溶栓，(3)排除脑血管事件。
